Results 121 to 130 of about 14,400,622 (245)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Financial Stability Report 2022: vulnerabilities and risks
, 2022 In its annual Financial Stability Report, Norges Bank assesses the financial stability outlook. The Report discusses cyclical and structural developments in financial markets, the Norwegian economy and among banks and other financial institutions that ...
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structural design report for LCS (low crested structures): Final report
, 2004 This report presents additional information and new formulae not included in Delos report D22. Existing formulae for the design of LCS's for coast protection structures can be found in D22 and are therefore not repeated in this report ...
Anonymous, A. (author)
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Financial Infrastructure Report 2018 [PDF]
, 2018 The Financial Infrastructure Report is part of Norges Bank’s work to promote financial stability and an efficient payment system in Norway. The Executive Board discussed the content of the Report on 2 May 2018.
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Council On The Advancement Of Standards
Journal of College Orientation, Transition, and Retention, 1984 NODA Report
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
, 1971 This report summarizes research conducted on tomatoes at the Horticultural Experiment Station, Simcoe, during 1971. The report was intended to inform research and extension colleagues and the industry of the then current trials on crop production and ...
Phatak, S.C.
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source