Results 161 to 170 of about 19,005,321 (291)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Examining social camouflaging and its cognitive, mental health and neurophysiological correlates in autistic adolescents through triangulation-based assessment using self, parent and daily diary reports: a study protocol. [PDF]

BMJ Open
Klein J, Krahn RL, Howe SJ, Cormier A, Rush J, Ames M, McMorris CA, Macoun S.   +7 more
europepmc   +1 more source

The Implications of National and Local Labour Markets for the Social Care Workforce [PDF]

, 2020
Ferguson, Adam, Hanks, Jeremy, Reid, Pamela, Thomas, Jennifer   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Systematic Review of Methods to Measure Adherence to Oral Anticancer Medications in African Women With Breast Cancer at Initiation, Implementation, and Discontinuation of Therapy. [PDF]

Int J Breast Cancer
Onwusah DO, Mindu T, Chimbari MJ, Ojewole EB.   +3 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Early-onset recipient-site necrosis after FUE hair transplantation complicated by <i>Pseudomonas aeruginosa</i> infection: a case report. [PDF]

J Surg Case Rep
Al-Mamoori A, Al-Hamamy Z, Al-Badri SG, Al-Hamamy H.   +3 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Comparison of event-specific drinking motives reported at the first drink versus retrospectively the next morning. [PDF]

Psychol Addict Behav
Boyle HK, López G, Carey KB, Jackson KM, Miranda R, Merrill JE.   +5 more
europepmc   +1 more source

EANF Learning Report 1: Evidence and Data [PDF]

, 2016
Bennett, Ellen, Damm, Christopher, Dayson, Christopher, Pearson, Sarah, Wells, Peter   +4 more
core