Results 111 to 120 of about 4,227,229 (295)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

First report of kleptoparasitism in Leptodeira rhombifera (Squamata, Dipsadidae) for a yellow toad Incilius luetkenii (Anura, Bufonidae) in Nicaragua [PDF]

Travaux du Muséum National d’Histoire Naturelle “Grigore Antipa”
Kleptoparasitism is a widely observed feeding strategy across various animal taxa. In snakes it is well documented in captivity, but rarely reported in the wild. This observation is the first of its kind in Nicaragua.
Milton Salazar-Saavedra, Rogemif D. Fuentes   +1 more
doaj   +3 more sources

Fourlined Plant Bug (Hemiptera: Miridae), a Reappraisal: Life History, Host Plants, and Plant Response to Feeding [PDF]

, 2017
Phenology of the fourlined plant bug, Poecilocapsus lineatus, is presented for southcen- tral Pennsylvania; life history and habits are re-examined. Although breeding was previously thought to occur only on woody plants, we found that nymphs develop on ...
Miller, Gary L, Wheeler, A. G, Jr
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Acceleration by Strong Interactions

, 2017
Beyond the attractive strong potential needed for hadronic bound states, strong interactions are predicted to provide repulsive forces depending on the color charges involved.
Erdmann, Martin, Glaser, Christian, Quast, Thorben   +2 more
core  

Phase mixing of propagating Alfven waves in a stratified atmosphere: Solar spicules

, 2012
Alfvenic waves are thought to play an important role in coronal heating and solar wind acceleration. Recent observations by Hinode/SOT showed that the spicules mostly exhibit upward propagating high frequency waves. Here we investigate the dissipation of
Altafi-Mehrabani, H., Ebadi, H., Hosseinpour, M.   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Thoroughly thought through? Experimenting with Registered Reports

European Journal of Social Psychology, 2021
Imhoff, R, Alexopoulos, T, Cichocka, A, Degner, J, Dixon, J, Easterbrook, MJ, Greenaway, KH, Henry, PJ, Marshall, T, Papies, EK, Rothmund, T, Shnabel, N, Smith, J   +12 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source