Results 51 to 60 of about 1,544,653 (305)

Detecting Temporal Cognition in Text: Comparison of Judgements by Self, Expert and Machine

open access: yesFrontiers in Psychology, 2018
Background: There is a growing research focus on temporal cognition, due to its importance in memory and planning, and links with psychological wellbeing.
Erin I. Walsh, Janie Busby Grant
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Challenges of Improving Patient-Centred Care in Parkinson’s Disease

open access: yesJournal of Parkinson’s Disease, 2017
Background: Parkinson’s disease is a neurodegenerative condition with a complex pattern of motor and non-motor symptoms. Of several clinical scales used to measure patient experience few are delivered by patients themselves.
Soania Mathur   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Cutaneous plasmacytosis: a case report and review of pulmonary findings

open access: yesDermatology Reports, 2011
Primary cutaneous plasmacytosis is an uncommon cutaneous disorder with multiple cutaneous nodules and plaques mainly on face and trunk. This entity is thought to be a reactive process with unknown etiology.
Weeranut Chantachaeng   +1 more
doaj   +1 more source

A Case of Ceruminous Adenocarcinoma Not Otherwise Specified (NOS) in the External Auditory Canal

open access: yesEar, Nose & Throat Journal, 2022
External auditory canal cancer is a rare disease which can be treated by surgery or chemoradiation. The most common histological type is squamous cell carcinoma, but rare types such as adenocarcinoma have been reported and are thought to be derived from ...
Kento Wada MD   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Empirical Illustration of the Hierarchical Organisation of Social Thought: A Domino Effect?

open access: yesInteramerican Journal of Psychology, 2009
The "architecture of social thinking", a model presented by Rouquette (1996) suggests that various forms of social thought may be conceived as being part of a hierarchical organisation.
Rafael Pecly Wolte   +2 more
doaj  

Human movement patterns predict task-unrelated thought.

open access: yesPLoS ONE
The cognitive phenomenon, known as task-unrelated thought, reflects the attention shift of one's mind away from the task at hand. Evidence suggests that task-unrelated thought occurs in 30-50% of people's waking time.
Aaron Y Wong   +4 more
doaj   +1 more source

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