Results 171 to 180 of about 657,091 (294)

Messenger RNA-encoded reporters for monitoring cellular stress and bioenergetics. [PDF]

Sci Rep
Hwang KK, Fang Q, Nizard C, Bulteau AL, Woltjen K.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Northern Reporter, 1984-08-22

, 1984
Northern Reporter, 1984-08 ...

core  

Exploring bet-hedging in <i>Salmonella enterica</i> serovar Typhimurium with a dual reporter strain. [PDF]

mSystems
Gerber MI, Sivaranjani M, Vincent K, Jelfimow S, Herman DJ, Palmer MB, Nnajide CR, Sanderson H, Sparrow J, Waddell BM, Dhar N, Wu C-W, White AP.   +12 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Northern Reporter, 1968-03-09

, 1968
Northern Reporter, 1968-03 ...

core  

Chromatin insulators homie and nhomie can interact with distant copies either together or separately, with distinct outcomes for enhancer-promoter interactions. [PDF]

PLoS Genet
Fujioka M, Ke W, Schedl P, Jaynes JB.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Northern Reporter, 1984-02-15

, 1984
Northern Reporter, 1984-02 ...

core  

Single-nucleus transcriptomics resolves multiple fate dynamics between inflorescence meristem and primary stem. [PDF]

Sci Adv
Moreno-Ramírez S, Lenz MO, Meyerowitz EM, Locke JCW, Jönsson H.   +4 more
europepmc   +1 more source