Results 241 to 250 of about 724,793 (282)

Transcriptional modulation of β-Secretase ameliorates amyloid pathology and cognitive deficits in Alzheimer's disease models. [PDF]

Signal Transduct Target Ther
Park J, Bae HG, Cho Y, Baek SH, Jo DG.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Type I restriction-modification systems regulate gene expression through DNA topology. [PDF]

Nucleic Acids Res
Althari Y, Chen YK, Menon A, Ferrándiz MJ, van Raaphorst R, De Ste Croix M, Ulijasz AT, Glanville DG, Veening JW, Bentley SD, Croucher NJ, Bayliss CD, de la Campa AG, Zhang JR, Trappetti C, Haigh RD, Oggioni MR.   +16 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Functional mapping and engineering of the Sec translocon unlocked by a cell-free system. [PDF]

Sci Adv
Meier M, Scholz SA, von Bank L, Levandoski JE, Lückhof M, Schaaf M, Safronova N, Greenwood NF, Si S, Lieberwirth I, Jung AL, Landfester K, Driessen AJM, Erb TJ.   +13 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Impact of Cistron Topology and Bicistronic Vector Design in the piggyBac Transposon System for Improved Antibody Expression. [PDF]

Biotechnol J
Vitko J, King T, Aral E, McLellan S, Divello H, Maimouni S, McLamarrah T, Tedstone J, Cairns V, DeMaria C, Scarcelli JJ.   +10 more
europepmc   +1 more source

Engineered fluorescence for live diagnostics and quantification of poxvirus infection. [PDF]

J Gen Virol
Lant S, Holley JA, Sumner RP, Ulaeto DO, Maluquer de Motes C.   +4 more
europepmc   +1 more source

Modulation of angiogenic transcription factor ERG via miR-6756 and miR-3190. [PDF]

PLoS One
Mumtaz S, Rashid MU, Khan SU, Malkani N.
europepmc   +1 more source