Results 51 to 60 of about 2,568,286 (273)

A Survey of Regional-Scale Blocking Patterns and Effects on Air Quality in Ontario, Canada

Atmosphere, 2018
Blocking weather patterns cause persistent weather situations that alter typical wind and circulation patterns which may result in stagnant weather conditions at the surface and potentially adverse conditions that affect society, such as extended warmth,
Frank Dempsey
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration [PDF]

, 2007
Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taking into account
Egger, Matthias, Douglas G Altman, Mulrow, Cynthia D, Cynthia D Mulrow, Charles Poole, Gøtzsche, PC, Altman, Douglas G, Pocock, SJ, von Elm, Erik, Schlesselman, JJ, Altman, DG, Stuart J Pocock, Von Elm, E, Altman, Douglas G., Mulrow, Cynthia D., STROBE, Initiative, Egger, M, James J Schlesselman, Gøtzsche, Peter C., Schlesselman, James J, Matthias Egger, STROBE Initiative, Mulrow, CD, Vandenbroucke, Jan P, Pocock, Stuart J, Poole, Charles, Vandenbroucke, Jan P., Erik von Elm, Gøtzsche, Peter C, Jan P Vandenbroucke, Elm, Erik von, Vandenbroucke, JP, Poole, C, Pocock, Stuart J., Schlesselman, James J., Peter C Gøtzsche   +35 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Electronic adverse incident reporting in hospitals

, 2010
The purpose of this study was to assess attitudes toward and use of an electronic adverse incident reporting system in all four hospitals in one NHS Scotland Health Board area.
Burns, Calvin, Antony, Jiju, Burns, C., Antony, J., Kerry Walsh, Calvin Burns, Jiju Antony, Walsh, Kerry, Walsh, K.   +8 more
core   +1 more source

Corporate social reporting by MNCs’ subsidiaries in Sri Lanka [PDF]

, 2013
This study examines the pressures, barriers and enablers which subsidiaries of multinational companies encounter when engaging in corporate social reporting within a developing country context. The researchers conducted in-depth interviews with eighteen
Eshani Beddewela, Beddewela, Eshani, Beddewela, E, Herzig, Christian, Christian Herzig, Herzig, C   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Narrative reporting by UK charities

, 2013
This study is the first in-depth study of the form and content of the narrative element of charities’ reporting documents. It offers insights into why charities choose to disclose (or not disclose) in their public reporting documents.Publisher ...
Connolly, Ciaran, Dhanani, Alpa
core