Results 101 to 110 of about 1,240,159 (279)

Guideline for reporting negative studies in biomedical journals

National Journal of Physiology, Pharmacy and Pharmacology, 2014
Negative studies are those where the in which authors fail to reject the null hypothesis after statistical analysis or in negative studies, authors typically conclude that there is “no significant difference” between the interventions for measured ...
Deepak Saxena, Jaykaran Charan
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reporting Guidelines for Community Outbreak Investigation Reporting (G-CORE): protocol for guideline development

The Ewha Medical Journal
Objectives: Outbreak reports are essential for documenting the spread of and responses to disease outbreaks. However, there is a lack of standardized reporting guidelines that encompass broader perspectives on
Wonyoung Jung, Sukhyun Ryu, So Yeon Ryu, Mina Ha, Bo Youl Choi, Soo Young Kim   +5 more
doaj   +1 more source

Reporting guideline for priority setting of health research (REPRISE)

BMC Medical Research Methodology, 2019
Background Research priority setting with stakeholders can help direct the limited resources for health research toward priority areas of need.
Allison Tong, Anneliese Synnot, Sally Crowe, Sophie Hill, Andrea Matus, Nicole Scholes-Robertson, Sandy Oliver, Katherine Cowan, Mona Nasser, Soumyadeep Bhaumik, Talia Gutman, Amanda Baumgart, Jonathan C. Craig   +12 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Establishing the Guidelines for Recommendation Reporting (G-RECO): a study protocol for developing reporting guidelines for disease prevention recommendations

The Ewha Medical Journal
Objectives: The objective of this study was to develop the Guidelines for Recommendation Reporting (G-RECO) for use in the Public Health Weekly Report (PHWR) in Korea, aiming to improve the ...
Wonyoung Jung, Sukhyun Ryu, So Yeon Ryu, Mina Ha, Bo Youl Choi, Soo Young Kim   +5 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Reporting randomised trials of physical exercise or training interventions in older adults: the PETIO guideline

European Review of Aging and Physical Activity
Objective This reporting guideline was developed to address the gap in methodological reporting standards for trials investigating physical exercise or training in older adults, aiming to enhance the quality, transparency, and replicability of such ...
Bettina Wollesen, Piesie A. G. Asuako, Mona Herden, Christoforos D. Giannaki, Antoine Langeard, Nicola Lamberti, Melanie Mack, Michel Audiffren, Yael Netz, Claudia Voelcker-Rehage   +9 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source