Results 151 to 160 of about 1,720,531 (278)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Maximizing the Quality and Reporting Standards of Autism Intervention Science. [PDF]

Autism Res
LaPoint S, Klein CB, Sandbank M, Bottema-Beutel K, Fletcher-Watson S, Divan G, Dimitriou D, Anagnostou E, Andersen ME, Binns A, Charman T, Estabillo JA, Fecteau SM, Ferrari A, Geoffray MM, Hampton LH, Hergüner S, Kuschner ES, Lee JYS, Segers J, Swain D, Vejnoska S, Vivanti G, Wang C, Green J.   +24 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Evaluating the performance of a generative AI model in assessing qualitative health research articles adherence to objective reporting standards. [PDF]

Sci Rep
Chia AW, Teo WL, Munro YL, Dalan R.
europepmc   +1 more source

Minimum Reporting Standards Should be Expected for Preclinical Radiobiology Irradiators and Dosimetry in the Published Literature. [PDF]

Radiat Res, 2023
Poirier Y, DeWerd LA, Trompier F, Santos MD, Sheng K, Kunugi K, Satyamitra MM, DiCarlo AL, Winters TA.   +8 more
europepmc   +1 more source

GCS programmer's manual [PDF]

A variety of instructions to be used in the development of implementations of software for the Guidance and Control Software (GCS) project is described.
Dent, Leslie A., Hayhurst, Kelly J., Lowman, Douglas S., Shagnea, Anita M., Withers, B. Edward   +4 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A review of use of external data and update on reporting standards in Sequential Multiple-Assignment Randomised Trials. [PDF]

Clin Trials
Egesa IJ, Bonnett L, Emsley R, Marson A, Smith CT.   +4 more
europepmc   +1 more source

Comparative study of ChatGPT and human evaluators on the assessment of medical literature according to recognised reporting standards. [PDF]

BMJ Health Care Inform, 2023
Roberts RH, Ali SR, Hutchings HA, Dobbs TD, Whitaker IS.   +4 more
europepmc   +1 more source

The Need to Adapt to New Financial Accounting Technologies Information in the Context of Global Economic Crisis [PDF]

Today, accounting is a necessity and not a desire. Concerns for the improvement of accounting practices are necessary, especially in Romania, where these activities are strengthened with the progress of the Romanian economy integration into the ...
Adrian LUPASC, Enrique BONSON-PONTE, Ioan ANDONE, Ioana LUPASC   +3 more
core