Results 141 to 150 of about 3,591,939 (354)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Potholes are a major challenge on urban roads, causing vehicle damage, traffic congestion, and safety hazards. This paper proposes a Pothole Detection and Reporting System that leverages computer vision, sensor data, and mobile connectivity to automatically identify and geo-tag potholes.
Tejas Randive +4 more
openaire +1 more source
A Unifying Model of How the Tax System and Generally Accepted Accounting Principles Affect Corporate Behavior [PDF]
This paper models the impact of the tax system and GAAP on the real and financial reporting decisions of corporations. It provides a first step toward joint evaluation of taxation and financial reporting in the standard economic analyses of corporate ...
Douglas A. Shackelford +2 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Communicable Disease Reporting Systems in the World: A Systematic Review Article
Iranian Journal of Public Health, 2015 Background: Communicable disease reporting and surveillance system has poor infrastructure and supporters in most of countries. Its quality improvement is a challenge and requires an accurate and efficient care and reporting systems at all levels to ...
Ali JANATI +4 more
doaj
International comparisons of post-compulsory education systems. Final report, May 2019 [PDF]
, 2019 David Greatbatch, Sue Tate
openalex
Public Price Reporting in the Cash Market for Live Cattle: A Spatial Market Approach [PDF]
Legislative authorization for the Livestock Mandatory Reporting Act of 1999 was renewed in October of 2006. One of the cited justifications for implementing mandatory reporting was that the voluntary reporting system for the slaughter cattle cash market ...
Diersen, Matthew A. +2 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Price Transparency in the Voluntary Price Reporting System for Live Cattle: Theory and Empirical Evidence [PDF]
Interregional spatial linkages between South Dakota and Nebraska cash markets for slaughter cattle are investigated. Econometric procedures are used to test whether a thinning market effect or strategic price reporting behavior by packers has degraded ...
Diersen, Matthew A. +2 more
core +1 more source