Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
New Estimates of the Index of Economic Well-being for Canada and the Provinces, 1981 - 2008 [PDF]
This report presents new estimates of the Index of Economic Well-being (IEWB) and its four domains (consumption flows, stocks of wealth, economic equality and economic security) for Canada and the provinces for the 1981-2008 period.
Andrew Sharpe, Lars Osberg
core
Significant Victories: The Practice and Promise of First Contracts in the Public and Private Sectors [PDF]
After decades of massive employment losses in heavily unionized sectors of the economy, and the exponential growth of the largely unorganized service sector, the American labor movement is struggling to remain relevant. Despite new organizing initiatives,
Bronfenbrenner, Kate +2 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Telling more than we can know: Verbal reports on mental processes.
R. Nisbett, Timothy D. Wilson
semanticscholar +1 more source
The Global Call Center Report: International Perspectives on Management and Employment (Executive Summary) [PDF]
[Excerpt] This report is the first large scale international study of call center management and employment practices across all regions of the globe – including Asia, Africa, South America, North America, and Europe. Covering almost 2,500 centers in 17
Batt, Rosemary +2 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Publishing in a Pandemic: The View from Cell Reports
The Cell Reports Editorial Team
doaj +1 more source
The Effect of Increasing Aboriginal Educational Attainment on the Labour Force, Output and the Fiscal Balance [PDF]
Investing in disadvantaged young people is one of the rare public policies with no equity-efficiency tradeoff. Based on the methodology developed in Sharpe, Arsenault and Lapointe (2007), we estimate the effect of increasing the educational attainment ...
Andrew Sharpe +2 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

