Results 11 to 20 of about 68,598 (172)

Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity

open access: yesBiomedicines, 2020
Adrenocortical carcinoma (ACC) presents a high risk of relapse and metastases with outcomes not improving despite extensive research and new targeted therapies.
Anida Hasanovic   +4 more
doaj   +1 more source

Preventing pressure ulcers in aged care by auditing, and changing, work practices

open access: yesAsian Journal of Medical Sciences, 2022
Background: Two nurse consultants concerned with ongoing pressure ulcer development in a 44-bed residential aged care facility in Sydney, Australia, audited pressure ulcers and the use of air mattresses.
Catherine Sharp , Julie Campbell
doaj   +1 more source

Factors Associated With Urgent-Start Peritoneal Dialysis Catheter Complications in ESRD

open access: yesKidney International Reports, 2020
Introduction: Urgent-start peritoneal dialysis (PD) in patients with newly diagnosed end-stage renal disease (ESRD) is a well-tolerated alternative to hemodialysis (HD).
José L. Hernández-Castillo   +7 more
doaj   +1 more source

ILM Flap Repositioning for Persistent Macular Hole

open access: yesCase Reports in Ophthalmology, 2022
We present a case of a persistent macular hole which was initially treated by pars plana vitrectomy with the inverted ILM flap technique. In a second procedure, the internal limiting membrane (ILM) flap was mobilized from its perifoveal adherence to the ...
Gregor Kastl, Peter Heidenkummer
doaj   +1 more source

Drug Repositioning: An Opportunity to Develop Novel Treatments for Alzheimer’s Disease

open access: yesPharmaceuticals, 2013
Alzheimer’s Disease (AD) is the most common cause of dementia, affecting approximately two thirds of the 35 million people worldwide with the condition. Despite this, effective treatments are lacking, and there are no drugs that elicit disease modifying ...
Clive Ballard   +2 more
doaj   +1 more source

Exposure of Paracoccidioides brasiliensis to Mebendazole Leads to Inhibition of Fungal Energy Production

open access: yesAntibiotics, 2023
Paracoccidioidomycosis (PCM) is a fungal disease caused by organisms of the genus Paracoccidioides spp. The treatment of the disease is lengthy and includes several adverse effects.
Olivia Basso Rocha   +5 more
doaj   +1 more source

Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic Review

open access: yesViruses, 2021
The immunological findings from autopsies, biopsies, and various studies in COVID-19 patients show that the major cause of morbidity and mortality in COVID-19 is excess immune response resulting in hyper-inflammation. With the objective to review various
Apparao Peddapalli   +5 more
doaj   +1 more source

Reichenbach’s Posits Reposited [PDF]

open access: yesErkenntnis, 2008
Reichenbach’s use of ‘posits’ to defend his frequentistic theory of probability has been criticized on the grounds that it makes unfalsifiable predictions. The justice of this criticism has blinded many to Reichenbach’s second use of a posit, one that can fruitfully be applied to current debates within epistemology.
Atkinson, D, Peijnenburg, A.J.M.
openaire   +1 more source

Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta‐analysis

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background There is a concern that resheathing/repositioning of transcatheter heart valves during transcatheter aortic valve implantation (TAVI) may lead to an increased risk of periprocedural complications.
Francesco Moroni   +7 more
doaj   +1 more source

The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
Chagas disease (CD) affects at least 6 million people in 21 South American countries besides several thousand in other nations all over the world. It is estimated that at least 14,000 people die every year of CD.
Juliana Almeida-Silva   +10 more
doaj   +1 more source

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