Results 31 to 40 of about 2,545,734 (238)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

NeuroVault.org: A web-based repository for collecting and sharing unthresholded statistical maps of the human brain

Frontiers in Neuroinformatics, 2015
Here we present NeuroVault — a web based repository that allows researchers to store, share, visualize, and decode statistical maps of the human brain. NeuroVault is easy to use and employs modern web technologies to provide informative visualization of ...
Krzysztof Jacek Gorgolewski, Krzysztof Jacek Gorgolewski, Gael eVaroquaux, Gabriel eRivera, Yannick eSchwartz, Satrajit S Ghosh, Camille eMaumet, Vanessa V Sochat, Thomas E. Nichols, Russell A. Poldrack, Jean-Baptiste ePoline, Tal eYarkoni, Daniel S. Margulies   +12 more
doaj   +1 more source

Davis Digital Repository Grant [PDF]

, 2005
The HELIN (Higher Education Library Information Network) Consortium, consisting of academic and health sciences libraries in Rhode Island and Massachusetts, has developed a plan to create a digital repository to archive, preserve and make accessible ...
Aspri, Bob, Sanders, Martha Rice
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Augmenting tomato functional genomics with a genome-wide induced genetic variation resource

Frontiers in Plant Science
Induced mutations accelerate crop improvement by providing novel disease resistance and yield alleles. However, the alleles with no perceptible phenotype but have an altered function remain hidden in mutagenized plants.
Prateek Gupta, Prateek Gupta, Pankaj Singh Dholaniya, Kunnappady Princy, Athira Sethu Madhavan, Yellamaraju Sreelakshmi, Rameshwar Sharma   +6 more
doaj   +1 more source

Review of entrepreneurship in the COVID-19 era

Revista Ingenio, 2022
In the Covid-19 era, the policies of confinement and distancing of people open up areas of opportunity that the present study set out to analyze. A documentary, systematic and retrospective work was carried out with a selection of sources indexed to ...
José Marcos Bustos Aguayo, Margarita Juárez Nájera, Cruz García Lirios   +2 more
doaj   +1 more source

Redefining the Institutional Repository [PDF]

, 2014
Institutional Repositories have grown in importance over the last 10 years to offer a core University and Library service, however, their role is developing faster now than it has ever done.
Keene, Chris
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Polimedia: Using advanced screencasting for effective e-learning content production

Læring og Medier, 2009
In this paper we present Polimedia, a system designed to help teachers producing high quality e-learning content without technological knowledge. We achieve this by using a special TV-like recording studio that gets teachers' video and learning material ...
Carlos Turro, Manuel Jimenez, Luis Morcillo, Jaime Busquets   +3 more
doaj   +1 more source

Consortial routes to effective repositories [PDF]

, 2009
A consortial approach to the establishment of repository services can help a group of Higher Education Institutions (HEIs) to share costs, share technology and share expertise.
Moyle, M., Proudfoot, R.
core