Results 41 to 50 of about 2,528,445 (262)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Polimedia: Using advanced screencasting for effective e-learning content production

open access: yesLæring og Medier, 2009
In this paper we present Polimedia, a system designed to help teachers producing high quality e-learning content without technological knowledge. We achieve this by using a special TV-like recording studio that gets teachers' video and learning material ...
Carlos Turro   +3 more
doaj   +1 more source

Consortial routes to effective repositories [PDF]

open access: yes, 2009
A consortial approach to the establishment of repository services can help a group of Higher Education Institutions (HEIs) to share costs, share technology and share expertise.
Moyle, M., Proudfoot, R.
core  

Security functions for a file repository [PDF]

open access: yes, 1996
When personal machines are incorporated into distributed\ud systems a new mixture of threats is exposed.\ud The security effort in the MobyDick project\ud is aimed at understanding how privacy can be protected\ud in this new environment.
Helme, Arne, Stabell-Kulo, Tage
core   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Augmenting tomato functional genomics with a genome-wide induced genetic variation resource

open access: yesFrontiers in Plant Science
Induced mutations accelerate crop improvement by providing novel disease resistance and yield alleles. However, the alleles with no perceptible phenotype but have an altered function remain hidden in mutagenized plants.
Prateek Gupta   +6 more
doaj   +1 more source

The Specifics of the Elective “School of Leadership” Using Repositories of Online Resources

open access: yesUniversity Library at a New Stage of Social Communications Development, 2023
Objective. Modern online library resources play an important role in the organisation and conduct of the School of Leadership elective. The purpose of this study is to consider the peculiarities of conducting the elective “School of Leadership” for ...
N. O. MYKYTENKO, A. M. KOTLOVSKYI
doaj   +1 more source

BlogForever: D3.1 Preservation Strategy Report [PDF]

open access: yes, 2013
This report describes preservation planning approaches and strategies recommended by the BlogForever project as a core component of a weblog repository design.
Arango-Docio, Silvia   +9 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Redefining the Institutional Repository [PDF]

open access: yes, 2014
Institutional Repositories have grown in importance over the last 10 years to offer a core University and Library service, however, their role is developing faster now than it has ever done.
Keene, Chris
core   +1 more source

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