Results 71 to 80 of about 2,528,445 (262)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Beyond Institutional Repositories [PDF]

International Journal of Digital Library Systems, 2009
The current system of so-called institutional repositories, even if it was a sensible response at an earlier stage, may not answer the needs of the scholarly community, scientific communication and accompanied stakeholders in a sustainable way. However, having a robust repository infrastructure is essential to academic work.
Romary, Laurent, Armbruster, Chris
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Coming late to the game: how to create a totally integrated (!) repository system [PDF]

, 2012
This paper recounts the experiences and lessons learned in developing a repository system from scratch, using Eprints and Symplectic Elements, at City University London. The system is called City Research Online (CRO).
Stewart, N.
core  

Future changes in tropical cyclone activity in the North Indian Ocean projected by high-resolution MRI-AGCMs [PDF]

, 2012
Open Access at publisher's web site: http://www.springerlink.com/content ...
A Arakawa, A Cherchi, A Kitoh, Akio Kitoh, AT Evan, AT Evan, CW Landsea, D Randall, DB Stephenson, GD Bell, H Douville, H Murakami, H Murakami, H Ueda, Hiroyuki Murakami, HJ Diamond, HL Tanaka, JS Kain, K Emanuel, K Emanuel, K Onogi, K-H Lau, KR Knapp, L Bengtsson, M Bister, M Sugi, M Sugi, M Sugi, M Zhao, M Zhao, Masato Sugi, NA Rayner, NH Saji, OP Singh, R Krishnan, R Mizuta, R Mizuta, RH Kripalani, S-P Xie, SJ Camargo, T Knutson, TR Knutson, TY Tanaka, V Ramanathan, WM Gray   +44 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Distribution af video – lige meget hvordan?

Læring og Medier, 2009
Artiklen omhandler løsninger til distribution af video og de faktorer, der kan være udslagsgivende, når man som underviser eller universitet skal vælge, hvilken man vil gøre brug af. De kommercielle løsninger såsom YouTube m.fl.
Diba Markus
doaj   +1 more source

The Availability of Human Biospecimens to Support Biomarker Research

Biomarker Insights, 2022
Preserved biospecimens held in biobank inventories and clinical archives are important resources for biomarker research. Recent advances in technologies have led to an increase in use of clinical archives in particular, in order to study retrospective ...
Tamsin E. Tarling, Jennifer A. Byrne, Peter H. Watson   +2 more
doaj   +1 more source

Centralized mouse repositories [PDF]

Mammalian Genome, 2012
Because the mouse is used so widely for biomedical research and the number of mouse models being generated is increasing rapidly, centralized repositories are essential if the valuable mouse strains and models that have been developed are to be securely preserved and fully exploited.
Donahue, Leah Rae, Hrabe de Angelis, Martin, Hagn, Michael, Franklin, Craig, Lloyd, K C Kent, Magnuson, Terry, McKerlie, Colin, Nakagata, Naomi, Obata, Yuichi, Read, Stuart, Wurst, Wolfgang, Hörlein, Andreas, Davisson, Muriel T   +12 more
openaire   +3 more sources

Now we are 13. Open Research Online becomes a teenager! [PDF]

, 2015
The history of the Open University (UK) institutional repository (Open Research Online) is one of changing requirements as defined by its research community, institutional administrators and external HE policy.
Biggs, Chris, Dowson, Nicola, Stiles, Alan   +2 more
core