Results 41 to 50 of about 5,858,806 (226)
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Spheres, 2017 We are witnessing an acceleration of the deployment of digital technologies in border regimes as well as in migratory practices. This does not necessarily make borders ‘smarter’, but it points to spiraling dynamics between border and migration practices to which digital technologies prove central.
openaire +6 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Feminism: Representation of Margaret and Kate in Sydney Sheldon\u27s Novel Master of the Game [PDF]
, 2015 This study deals with the feminism representation of Margaret and Kate in SydneySheldon\u27s novel Master of the Game. The objectives are to describe thedifferences and similarities of two woman characterizations namely Margaret andKate and to reveal the
Dirgayasa, Y. R. (Yohana)
core
Intelligence with representation
Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, 2003 Behaviour-based robotics has always been inspired by earlier cybernetics work such as that of W. Grey Walter. It emphasizes that intelligence can be achieved without the kinds of representations common in symbolic AI systems. The paper argues that such representations might indeed not be needed for many aspects of sensory-motor intelligence but become ...
openaire +5 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Representations of bornologies
Applied General Topology, 2022 Bornologies abstract the properties of bounded sets of a metric space. But there are unbounded bornologies on a metric space like $\mathcal{P}(\RR)$ with the Euclidean metric. We show that by replacing $[0,\infty)$ with a partially ordered monoid every bornology is the set of bounded subsets of a generalized metric mapped into a partially ordered ...
openaire +3 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
2011 Conference Record of the Forty Fifth Asilomar Conference on Signals, Systems and Computers (ASILOMAR), 2011 Sparse representations, where one seeks to represent a vector on a redundant basis using the smallest number of basis vectors, appears to have numerous applications. The other extreme, where one seeks a representation that uses all the basis vectors, might be of interest if one manages to spread the information nearly equally over all of them ...
openaire +5 more sources