Results 51 to 60 of about 1,628,036 (248)

European Research Area

open access: yesForesight and STI Governance, 2007
Europe is in transition to a new model of economic development. To this end, the EU creates a common research space, a kind of pan-European marketplace of ideas, research, innovation.
Richard Burger
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Effectiveness of European Open Science Policies on Improving Economic Competitiveness

open access: yesGiLE Journal of Skills Development
This study evaluates the European Commission’s strategy to enhance innovation and competitiveness through the research, innovation and development (R&I&D) sector, with a particular focus on Open Science (OS).
István Kárász
doaj   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

The Points of Concurrence Theory in Guidobaldo del Monte’s Scenography

open access: yesDiségno, 2018
Theatrical scenography was one of the privileged applications of perspective in the Renaissance. The court theater, characteristic of those years, is structured around a frontal perspective installation developed in depth.
Leonardo Baglioni, Marta Salvatore
doaj  

Ethnoracial Representation in Hidradenitis Suppurativa Clinical Trials [PDF]

open access: green, 2022
Kareem G. Elhage   +9 more
openalex   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

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