Results 121 to 130 of about 1,587,400 (284)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Projection subspace clustering
Journal of Algorithms & Computational Technology, 2017 Gene expression data is a kind of high dimension and small sample size data. The clustering accuracy of conventional clustering techniques is lower on gene expression data due to its high dimension.
Xiaoyun Chen, Mengzhen Liao, Xianbao Ye
doaj +1 more source
On the center of 3-dimensional and 4-dimensional Sklyanin algebras
, 2016 In this article, a new proof is given of the description of the center of quadratic Sklyanin algebras of global dimension three and four and the center of cubic Sklyanin algebras of global dimension three.
De Laet, Kevin
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
THE PARTITION DIMENSION OF CYCLE BOOKS GRAPH B_(m,n) WITH A COMMON PATH P_2
BarekengSuppose is a connected graph with elements of a set of vertices denoted by and a subset of . The distance between and is the shortest distance to every vertex in . Let be a partition of , where each subset belongs to .
Jaya Santoso, Darmaji Darmaji
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Bounds on multiplicities of symmetric pairs of finite groups
Forum of Mathematics, SigmaLet $\Gamma $ be a finite group, let $\theta $ be an involution of $\Gamma $ and let $\rho $ be an irreducible complex representation of $\Gamma $ .
Avraham Aizenbud, Nir Avni
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source