Results 201 to 210 of about 13,937,425 (345)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Beyond genomes: functional signatures reveal evolutionary patterns across the tree of life. [PDF]

Mol Biol Evol
Muñoz-Mérida A, Muñoz-Pajares AJ.
europepmc   +1 more source

Partitions of natural numbers with the same representation functions

, 2009
Yong-Gao Chen, M. Tang
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Testing the Robustness of the Genetic Algorithm on the Floating Building Block Representation.

, 1996
Recent studies on a floating building block representation for the genetic algorithm (GA) suggest that there are many advantages to using the floating representation.
Annie S. Wu, Building Block Representation, Robert Lindsay   +2 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Wendel-Gautschi-Kershaw's Inequalities and Sufficient and Necessary Conditions that a Class of Functions Involving Ratio of Gamma Functions are Logarithmically Completely Monotonic

, 2007
In the article, sufficient and necessary conditions that a class of functions involving ratio of Euler’s gamma functions and originating from Wendel-Gautschi-Kershaw’s double inequalities are logarithmically completely monotonic are presented.
Qi, Feng, Guo, Bai-Ni
core  

Hardware-Efficient Real-Valued Neural Predistorter for Multimode Power Amplifiers. [PDF]

Sensors (Basel)
Freire LBC, Schuartz L, Lima EG.
europepmc   +1 more source

Representation functions of sequences in additive number theory

, 1978
M. Nathanson
semanticscholar   +1 more source