Results 211 to 220 of about 371,688 (306)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

(289) Quality and Representation of Peyronie’s Disease Content on Social Media [PDF]

Nicholas Corsi, Scott W. Roberts, Marc Lafrance, Corey Able, Taylor P. Kohn, Niki Parikh   +5 more
openalex   +1 more source

Comparing Images of Depression in Mass Media and AI-Generated Pictures: Mixed Methods Study.

JMIR Hum Factors
Saladie N, Llorente C, Joosten R, Revuelta G.   +3 more
europepmc   +1 more source

Women oncologists across 18 Latin American countries: A multinational survey of professional barriers, leadership, and pay equity. [PDF]

Dialogues Health
Aviles L, Paz LR, Ballón K, Barahona K, Benítez A, Mata D, Cruz N, Lara ME, Gómez R, Loaiza LM, López B, Faroni L, Schwartzmann R, Ugarte E, Yañez L, Torrico MDC, Domínguez J, Rodriguez G, Amarillo D, Hurtado I, Aboelhassan R, Pinto C.   +21 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

'Putting food on the table': a critical discourse analysis of media representation of First Nations food insecurity in Australia. [PDF]

Int J Equity Health
Bramwell L, Cox L, Gallegos D.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Depression-Related Stigma Among Black and Latinx Youths: Guidance for Stigma Reduction Interventions. [PDF]

Psychiatr Serv
Jankowski SE, Pope LG, Lewis-Fernández R, Dixon LB, Amsalem D.   +4 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source