Results 51 to 60 of about 2,210,762 (272)

Learning task-state representations [PDF]

open access: yesNature Neuroscience, 2019
Arguably, the most difficult part of learning is deciding what to learn about. Should I associate the positive outcome of safely completing a street-crossing with the situation 'the car approaching the crosswalk was red' or with 'the approaching car was slowing down'?
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The Benefit of Multitask Representation Learning [PDF]

open access: yes, 2016
We discuss a general method to learn data representations from multiple tasks. We provide a justification for this method in both settings of multitask learning and learning-to-learn.
Maurer, Andreas   +2 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Learning representations of learning representations

open access: yes
The ICLR conference is unique among the top machine learning conferences in that all submitted papers are openly available. Here we present the ICLR dataset consisting of abstracts of all 24 thousand ICLR submissions from 2017-2024 with meta-data, decision scores, and custom keyword-based labels.
González-Márquez, Rita, Kobak, Dmitry
openaire   +2 more sources

Deep Multimodal Representation Learning from Temporal Data

open access: yes, 2017
In recent years, Deep Learning has been successfully applied to multimodal learning problems, with the aim of learning useful joint representations in data fusion applications.
Bernal, Edgar A.   +5 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Knowledge Graphs in Education and Employability: A Survey on Applications and Techniques

open access: yesIEEE Access, 2022
Studies on the relationship between education and employability are of paramount importance for policy makers, training institutions, companies and students. The availability of large scale data on the Internet, such as online job ads, has been leveraged
Yousra Fettach   +2 more
doaj   +1 more source

Hierarchical Representation Learning for Kinship Verification

open access: yes, 2017
Kinship verification has a number of applications such as organizing large collections of images and recognizing resemblances among humans. In this research, first, a human study is conducted to understand the capabilities of human mind and to identify ...
Kohli, Naman   +4 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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