A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
A análise de uma aula sobre o ensino das operações matemáticas básicas a luz da teoria dos registros de representação semiótica<br>Analysis of a class on the teaching of basic mathematical operations in the light of the theory of semiotic representation records [PDF]
, 2019 Jéssica Cravo Santos Bernardino
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HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
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Neural traces of composite tasks in complex task representation in the human brain reflects learning performance. [PDF]
PLoS BiolLee WT, Hazeltine E, Jiang J.
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FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
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Logics for stable and unstable mereological relations
Open Mathematics, 2011 Nenchev Vladislav
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Gridography tractography reveals communication between key areas from global workspace and integrated information theories of consciousness. [PDF]
Sci RepLori N, Machado J.
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FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Phenomenal interface theory: a model for basal consciousness. [PDF]
Philos Trans R Soc Lond B Biol SciKlein C, Barron AB.
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