Results 261 to 270 of about 3,100,522 (340)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Multi-task learning by using contextualized word representations for syntactic parsing of a morphologically rich language. [PDF]

PLoS One
Ehsan T, Butt M, Hussain S, Alhuzali H, Al-Laith A.   +4 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

The principles behind equivariant neural networks for physics and chemistry. [PDF]

Proc Natl Acad Sci U S A
Kondor R.
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Computer-Interpretable Quality Indicators for Intensive Care Medicine: Development and Validation Study.

J Med Internet Res
von Dincklage F, Bublitz VK, Kumpf O, Jurth C, Riessen R, Deja M, Schewe CM, Schädler D, Fuchs C, Gibb S, Scheer C, Schewe JC, Nowak H, Balzer F, Adamzik M, DIVI Information Technology Section, DIVI Quality and Economy Section, Marx G, Lichtner G.   +18 more
europepmc   +1 more source

Bag-of-words is competitive with sum-of-embeddings language-inspired representations on protein inference. [PDF]

PLoS One
Papadopoulos F, Sanchez-Elsner T, Niranjan M, Heinson AI.   +3 more
europepmc   +1 more source

Account of an improvement in the machine for producing engravings of medals, busts, &c. directly from the objects themselves, in which the distortions hitherto attending such representations are entirely obviated [PDF]

C. Blacklewar
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

XXXIII. Observations on a Picture in Gloucester Cathedral, and some other Representations, of the Last Judgment [PDF]

Gian Paolo G. Scharf
openalex   +1 more source