Results 101 to 110 of about 167,447,858 (248)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Processing postmodern spatiality

, 2015
This paper is concerned with exploring the relation between movement and spatiality in the postmodern- of how we move, how we experience spatiality and the implications of such a relation.
Ng, Esther Xinlin
core  

On the local Langlands correspondence for non-tempered representations [PDF]

, 2013
Let G be a reductive p-adic group. We study how a local Langlands correspondence for irreducible tempered G-representations can be extended to a local Langlands correspondence for all irreducible smooth representations of G.
Solleveld, Maarten, Solleveld, M. (Maarten), Aubert, A.-M., Plymen, R., Baum, P., Plymen, Roger, Anne-marie Aubert, Aubert, Anne-Marie, Paul Baum, Aubert, A. (Anne-Marie), Plymen, R. (Roger), Baum, Paul, Maarten Solleveld, Roger Plymen, Solleveld, M., Baum, P.F. (Paul)   +15 more
core   +1 more source

Scale Politics Amid Spatial Governance: A Case Study of the Guangdong-Hong Kong-Macao Greater Bay Area

Redai dili
Rapid regional economic development and urban growth in China pose new theoretical and practical demands for enhanced national spatial governance. However, existing political science theories, such as scientific hierarchy, block politics, and corporatism,
Qu Sicheng, Cao Xiuting, Zhou Zihang
doaj   +1 more source

Cultural Implications Regarding Privacy in Digital Contact Tracing Algorithms: Method Development and Empirical Ethics Analysis of a German and a Japanese Approach to Contact Tracing. [PDF]

J Med Internet Res, 2023
Haltaufderheide J, Viero D, Krämer D.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Representations of Disability in Qur’anic Narratives [PDF]

In some Muslim cultures disabled people are ridiculed, abused and face social injustice. Whilst there are texts which examine the representations of disabled people in a range of legal, social, religious, and cultural Muslim documents, there is a pau ...
Codina, G., Akbar, A.
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source