Results 121 to 130 of about 89,660 (330)

Physicality and Cooperative Design [PDF]

open access: yes, 2008
CSCW researchers have increasingly come to realize that material work setting and its population of artefacts play a crucial part in coordination of distributed or co-located work.
A. Dix   +27 more
core   +5 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Being and Time: Max Frisch’s Homo faber

open access: yesRevista de Filología Alemana, 2002
Time plays a central role in Max Frisch’s Homo faber. Reading the autobiographic entries that comprise the novel necessitates navigating a convoluted temporal structure.
Monica Birth
doaj  

Spectres, conjuration et invocation (de la guerre) dans les représentations de la crise. Une réflexion à partir du droit de crise

open access: yesAstérion
Emergency powers are shaped by representations of war. For proof of this, we not only need to observe the origins of a large part of this kind of law, but also the more or less explicit model provided by war in many interpretations of emergency ...
Marie Goupy
doaj   +1 more source

Temps numériques et contretemps pédagogiques en Collège Connecté

open access: yesDistances et Médiations des Savoirs, 2016
From September, 2013 till June, 2015, our team of eight researchers and four students immersed themselves for 2 school years in the everyday life of a connected Middle School (COCON) in Brittany (France).
Pascal Plantard
doaj   +1 more source

Reduction [PDF]

open access: yes, 2016
Reduction and reductionism have been central philosophical topics in analytic philosophy of science for more than six decades. Together they encompass a diversity of issues from metaphysics and epistemology.
Hüttemann, Andreas, Love, Alan
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Experiencias didácticas en el nivel superior sobre el tratamiento de la temporalidad en clases de historia medieval y moderna

open access: yesClio y Asociados, 2019
Historical time is a fundamental epistemological category to explain historical processes and it is generally assumed that students understand it by simply reading and studying historiographical texts. However, the difficulties presented by students in a
Carlos Marcelo Andelique   +1 more
doaj   +1 more source

Priority Monism Beyond Spacetime [PDF]

open access: yes, 2017
I will defend two claims. First, Schaffer's priority monism is in tension with many research programs in quantum gravity. Second, priority monism can be modified into a view more amenable to this physics.
Le Bihan, Baptiste
core   +6 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

open access: yesFEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner   +6 more
wiley   +1 more source

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