Results 51 to 60 of about 2,039 (267)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Representation learning with a temporally coherent mixed-representation.
, 2017 Guiding a representation towards capturing temporally coherent aspects present invideo improves object identity encoding. Existing models apply temporal coherenceuniformly over all features based on the assumption that optimal encoding of objectidentity only requires temporally stable components.
openaire +3 more sources
Telling time: representations of ruins in the grotesques of sixteenth-century Italy
Journal of Aesthetics & Culture, 2016 Prospects of ruins feature frequently within the grotesques or ornamental frescoes of sixteenth-century Italy. What is at stake in the representations of ruins seems to be at stake on a more general level in the grotesques seen as a compositional device:
Maria Fabricius Hansen
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Une antinomie durkheimienne… et au-delà
Temporalités, 2008 For sociologists, time has always been an intellectual enigma. Lately, another concept – temporality – has been preferred in contemporary sociological research.
Michel Lallement
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Information Loss in Temporal Knowledge Representations [PDF]
The Computer Journal, 1993 Summary: The problem of memory overflow and the efficient storage and retrieval of temporal knowledge is discussed. For temporal systems, dealing with continuous streams of time-ordered data, the problem of freeing memory is an important one. For humans the problem is one of selective forgetting and reorganisation of memory.
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source