Results 51 to 60 of about 2,050 (267)
Telling time: representations of ruins in the grotesques of sixteenth-century Italy
Journal of Aesthetics & Culture, 2016 Prospects of ruins feature frequently within the grotesques or ornamental frescoes of sixteenth-century Italy. What is at stake in the representations of ruins seems to be at stake on a more general level in the grotesques seen as a compositional device:
Maria Fabricius Hansen
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Brussels Studies, 2015 The spatial analysis of a literary text published in the mid 19th century allows a rediscovery of the panoramic literature genre and the wealth of information it provides about the urban context in which it was born.
Tatiana Debroux +3 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Information Loss in Temporal Knowledge Representations [PDF]
The Computer Journal, 1993 Summary: The problem of memory overflow and the efficient storage and retrieval of temporal knowledge is discussed. For temporal systems, dealing with continuous streams of time-ordered data, the problem of freeing memory is an important one. For humans the problem is one of selective forgetting and reorganisation of memory.
openaire +2 more sources
Une antinomie durkheimienne… et au-delà
Temporalités, 2008 For sociologists, time has always been an intellectual enigma. Lately, another concept – temporality – has been preferred in contemporary sociological research.
Michel Lallement
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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