Results 241 to 250 of about 120,380 (313)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Deep Learning-Driven Framework Integrating Organoid-Based Functional Validation Identifies Universal Neoantigens from Recurrent Glioma Mutations. [PDF]

Cancer Res
Wang C, Sun T, He Y, Yu M, Pan CQ, Hu H, Sun Y, Wang D, Cui Z, Zhang J, Zhai Y, Shi Z, Li Z, Xu M, Oh YT, Jiang T, Xu Z, Li G, Zhang J, Zhang W.   +19 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Functional development of photoreceptors in human retinal organoids. [PDF]

Stem Cell Res Ther
Zhang Y, Du M, Wang YH, Li M, Jin K, Pan D, Zhang X, Jin ZB.   +7 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Traditional Islam in Kazakhstan: historical formation, state discourse, and contemporary challenges. [PDF]

Front Sociol
Kerim S, Kurmanaliyev M.
europepmc   +1 more source

Adolescent and Parent Perceptions of Legitimacy of Parental Authority: Developmental trajectories and relation to adjustment outcomes. [PDF]

Int J Behav Dev
Levy SA, Colder CR, Schwartz-Mette RA.
europepmc   +1 more source

Nisin and rutin as potential coating agents for iron oxide nanoparticles for enhanced theranostic applications against cancer. [PDF]

Sci Rep
Saad OA, Elfiky AA, Fathy MM, Ibrahim IM, Ibrahim MA, Elgharib AM, Ali OA, Ezat AA.   +7 more
europepmc   +1 more source

Adolescent and Youth Sexual Reproductive Health (AYSRH): Perceived Religious Health Assets of Churches and Their Optimization for Youth Sexual Health in South Africa's Vaal Region. [PDF]

Healthcare (Basel)
Magezi V.
europepmc   +1 more source

Emergency medical preparedness and response for mass gatherings: Papua New Guinea emergency medical team's experience during Pope Francis's 2024 visit. [PDF]

Western Pac Surveill Response J
Oli U, Nou GG, Hosea R, Konigala K.
europepmc   +1 more source