Results 221 to 230 of about 577,757 (250)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Bioinformatics-driven insights: rapamycin-mediated CaMK2D inhibition alleviates intestinal ischemia-reperfusion injury. [PDF]

Front Immunol
Sheng R, Liang Y, Zhang H, Lai Y, Hong H, Huang D, Liu D.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Molecular Networking-Guided Phytochemical Profiling and Anti-Inflammatory Evaluation of Honglanqi, an Underutilized Commercial Specification of Astragali Radix. [PDF]

Plants (Basel)
Tan X, Wang A, Li H, Yin M, Peng H.
europepmc   +1 more source

miR-19a-3p and miR-19b-3p Promote Microglia Activation Associated With Neuroinflammation. [PDF]

J Neurosci Res
Sahebdel F, Battaglino RA, Morse LR, Olson JK.   +3 more
europepmc   +1 more source

Context-Dependent Effects of Maca Extracts on Signaling, Apoptosis, and Lipid Metabolism Markers in Prostate Cancer Mono- and Co-Culture Models. [PDF]

Cells
Olichwier AJ, Bruzgo-Grzybko M, Kalita IS, Golonko A, Bielicka N, Chabielska E, Gromotowicz-Poplawska A.   +6 more
europepmc   +1 more source

Effects of Benzo[a]pyrene on Targeted Therapy Response and Platelet-Activating Factor-Receptor-Mediated Microvesicle Particle Release in Non-Small Cell Lung Cancer. [PDF]

Med Sci (Basel)
Rawal R, Thyagarajan A, Sahu RP.
europepmc   +1 more source

Evaluating the Antioxidant, Cytoprotective and Wound-Healing-Associated Effects of <i>Haberlea rhodopensis</i> Ethanolic Extract in Human Skin Keratinocytes. [PDF]

Int J Mol Sci
Ermogenous A, Sarigiannidou E, Psomiadou M, Panagiotidou A, Voulgaridou GP, Kiousi DE, Moyankova D, Djilianov D, Galanis A, Pappa A.   +9 more
europepmc   +1 more source

Characterization of the Effect of α-Lipoic Acid in Human Macrophages Infected with <i>Mycobacterium tuberculosis</i>. [PDF]

Int J Mol Sci
Salustri A, Cappelletti G, De Maio F, Shen Y, Nuzzi F, Palucci I, Paglione F, Sanguinetti M, Sali M, Delogu G.   +9 more
europepmc   +1 more source