Results 61 to 70 of about 1,933,509 (376)
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Politics and GovernanceConspiracy theories gained considerable attention during the Covid-19 pandemic. Although studies have extensively explored their (mostly) negative impacts on various political and social aspects, like participation, health-related behavior, and violence,
Anne Küppers
doaj +1 more source
Populism as a narrative and the crisis of representative democracy
Revista CIDOB d'Afers Internacionals, 2018 In this article a critical analysis is made of some of the most influential approaches to contemporary populism and an alternative hypothesis is proposed.
Camil Ungureanu, Ivan Serrano
doaj +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Revista da Faculdade de Direito UFPR, 2015 Due to globalization, the state lost its monopoly on political mediation. For example, it began to share decisions with multiple stakeholders, internal and external, and is not able to control several variables that interfere in national life.
Murilo Gaspardo
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
In this paper we present a citizen-candidate model of representative democracy with endogenous lobbying. We find that lobbying induces policy compromise and always affects equilibrium policy outcomes.
Antonio Merlo, Leonardo Felli
core +6 more sources
Dados: Revista de Ciências Sociais, 1998 The article takes issue with positions that reduce representative systems to democratic linearity, considering how the latter is restricted to variations in forms of government and electoral systems that do not correspond to the growing complexity of ...
Santos Wanderley Guilherme dos
doaj
Reimagining direct democracy as an intersection of different forms of representation [PDF]
Pravni Zapisi, 2020 As an exceptional device in the life of contemporary constitutional democracies, direct democracy is normally considered to be separate from representation.
Miloš Matija
doaj
Representative democracy and the implementation of majority-preferred alternatives
Social Choice and Welfare, 2015 In this paper, we contrast direct and representative democracy. In a direct democracy, individuals have the opportunity to vote over the alternatives in every choice problem the population faces. In a representative democracy, the population commits to a
K. Coffman
semanticscholar +1 more source