Results 111 to 120 of about 357,026 (288)
Leadership Representativeness in the Australian Union Movement [PDF]
, 2000 This paper explores the dimensions of political and personal representativeness in the context of Australian unionism in the period since World War Two.
Bramble, T. J.
core
User Constrained Thumbnail Generation using Adaptive Convolutions
, 2019 Thumbnails are widely used all over the world as a preview for digital images. In this work we propose a deep neural framework to generate thumbnails of any size and aspect ratio, even for unseen values during training, with high accuracy and precision ...
Bhunia, Ayan Kumar +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Woodland: Geographical and Forest Inventory Indications and Criteria (Continuation. Beginning in N. 1, 2014) [PDF]
Сибирский лесной журнал, 2014 The definition of woodland is discussed. The structure and dynamics of forestland are considered on the example of the Tankhoisky forestry district in the South Baikal region.
R. A. Ziganshin
doaj
The Malawi Diffusion and Ideational Change Project 2004-06 [PDF]
In this paper, we evaluate the quality of survey data collected by the Malawi Diffusion and Ideational Change Project by investigating four potential sources of bias: sample representativeness, interviewer effects, response unreliability and sample ...
Francis Obare +4 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Representativeness and significance factors in ESP texts [PDF]
Ibérica, 2000 The development of communicative approaches and strategies in specialized discourse has led to revising notions of representative and significant language .
Alejandro Curado Fuentes
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source