Results 141 to 150 of about 424,116 (333)
Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio +13 morewiley +1 more sourceMolecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed +12 morewiley +1 more source2023 Aerospace & Electronic Systems Society: Organization and Representatives [PDF]
, 2023 Mark Davis, Sabrina Greco, Secretary -Kathleen Kramer, Alexander Charlish, Peter Willett, Steve Butler, Lorenzo Lo, Lance Kaplan, Michael Braasch, Jemma Malli, Laura Anitori, Michael Cardinale, Stefano Coraluppi, Braham Himed, Monte Willett, Alfonso Farina, Maria Greco, Hugh Griffiths, Puneet Mishra, Laila Moreira, Bob Rassa, Michael Noble, Roberto Sabatini, William Dale, Blair Brown, Joe Fabrizio, Francesca Filippini, Wolfgang Koch, Luke Rosenberg, Marina Ruggieri, George Schmidt, Fulvio Gini, M Barry, Carlton Award -Gokhan, Inalhan Harry, Rowe Mimno, Daniel O'hagan, Warren White, Award -Scott Goldstein, Daniel Tazartes, Fred Nathanson, Award -Braham Himed, Robert Hill, Judith Space, Kathleen Kramer, Tutorials -W Dale, Francesca Filippinni, ; Philipp, Markiton Strategic, Planning -Sabrina Greco, Michael Avionics, Aloke Roy, Claudio Sacchi, Accelerometer Panel, Jason Bingham, Joe Dauncey, Ieee Autotestcon -Bob, Dan Rassa, Walt Walsh, Downing, Pasquale Daponte, Fusion -W Dale Blair, Yvonne Gray, Paola Escobari Vargas +63 moreopenalex +1 more sourceTranscriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more source