Results 161 to 170 of about 2,422,307 (349)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Big Questions for Social Media Big Data: Representativeness, Validity and Other Methodological Pitfalls

, 2014
Zeynep Tüfekçi
openalex   +2 more sources

Auto-Brewery as an Emerging Syndrome: Three Representative Case Studies [PDF]

, 2015
Barbara Cordell, Anup K. Kanodia, B Cordell, J Mccarthy, A Reid, S Greene, C Jernberg, S Lofmark, C Edlund, J Jansson, T Ding, P Schloss, M Arumugam, J Raes, E Pelletier, Le Paslier, D Yamada, T, E Davenport, O Mizrahi-Man, K Michelini, L Barreiro, C Ober, M Hullar, B Fu, T Yatsunenko, F Rey, M Manary, I Trehan, M Dominguez-Bello, T Ghosh, S Gupta, T Bhattacharya, D Yadav, A Bark, A Zihler, M Gagnon, C Chassard, C Lacroix, J Goldsmith, R Sartor, M Jones, C Tomaro-Duchesneau, S Prakash, A Kostic, R Xavier, D Gevers, E Mayer, T Savidge, R Shulman, W Bye, N Ishaq, T Bolin, V Duncombe, S Riordan, C Chassard, M Dapoigny, K Scott, L Crouzet, C Del'homme, T Arora, R Sharma, M Aldeyab, M Scott, M Kearney, Y Alahmadi, F Magee, A Schubert, M Rogers, C Ring, J Mogle, J Petrosino, C Parra-Herran, L Pelaez, J Sola, A Urbiztondo, M Rodriguez, C Jacobs, Coss Adame, E Attaluri, A Valestin, J Rao, S, G Nucera, M Gabrielli, A Lupascu, E Lauritano, A Santoliquido, A Lupascu, M Gabrielli, E Lauritano, E Scarpellini, A Santoliquido, A Riquelme, M Calvo, A Guzman, M Depix, P Garcia, W Olver, S James   +99 more
openalex   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Exploring how patient involvement is enacted in the Swedish national system for knowledge-driven management - "work as imagined and work as done". [PDF]

BMC Health Serv Res
Petersson C, Määttä S, Gäre BA, Henriks G, Ånfors H, Nilsagård Y.   +5 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Engaging patients and researchers in RECOVER clinical trial protocol development: Key lessons. [PDF]

J Clin Transl Sci
Leverty R, Sutton S, Jackson C, Cerda M, Chang A, Zimmerman K.   +5 more
europepmc   +1 more source

PARTICIPATION OF ATTORNEY AS A REPRESENTATIVE IN ADMINISTRATIVE COURTS

, 2019
Dilshod Egamberdiyev
openalex   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source