Results 161 to 170 of about 729,095 (196)

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

Advanced Science, EarlyView.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng, Tiexi Yu, Fang Lv, Weiquan Li, Hongmei Yang, Xiaoping Zhang, Wen Xiao   +6 more
wiley   +1 more source

Repression of mab_1999 impairs growth and alters cellular morphology of Mycobacterium abscessus. [PDF]

BMC Microbiol
Ilmi AFN, Kaewsapsak P, Rotcheewaphan S.
europepmc   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Two-way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3. [PDF]

FEBS Open Bio
Ueno R, Terasaki A, Imai Y, Kimura Y, Kojima Y, Irie M, Odaira K, Noura M, Okamoto S, Yasuda T, Tsuzuki S, Kiyoi H, Hayakawa F.   +12 more
europepmc   +1 more source

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis

Advanced Science, EarlyView.
A multi‐agent AI (AI co‐scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti‐fibrotic efficacy and toxicity of these drugs is assessed in multi‐lineage human hepatic organoids grown in microwells (microHOs).
Yuan Guan, Lu Cui, Jakkapong Inchai, Zhuoqing Fang, Jacky Law, Alberto Alonzo Garcia Brito, Annalisa Pawlosky, Juraj Gottweis, Alexander Daryin, Artiom Myaskovsky, Lakshmi Ramakrishnan, Anil Palepu, Kavita Kulkarni, Wei‐Hung Weng, Zhuanfen Cheng, Vivek Natarajan, Alan Karthikesalingam, Keran Rong, Yunhan Xu, Tao Tu, Gary Peltz   +20 more
wiley   +1 more source

DDX6 interacts with DDX3X to repress translation in microRNA-mediated silencing. [PDF]

Nucleic Acids Res
Lu Y, Tao M, Su H, Tu Y, Wang JP, Kuroda M, Wang X.   +6 more
europepmc   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Remodeling of Germ Cell mRNPs for Translational Control. [PDF]

Biology (Basel)
Keiper BD, Huggins HP.
europepmc   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analyses uncover novel genetic targets for enhanced l-tryptophan production in <i>Corynebacterium glutamicum</i>. [PDF]

Synth Syst Biotechnol
Dong Y, Gao R, Qin N, Liu K, Liu Y, Chen Z.   +5 more
europepmc   +1 more source