Results 111 to 120 of about 297,096 (313)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Insight into microRNA regulation by analyzing the characteristics of their targets in humans

BMC Genomics, 2009
Background microRNAs (miRNAs) are believed to regulate their targets through posttranscriptional gene regulation and have the potential to silence gene expression via multiple mechanisms.
Hu Zihua
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Recognising Desire: A psychosocial approach to understanding education policy implementation and effect [PDF]

, 2006
It is argued that in order to understand the ways in which teachers experience their work - including the idiosyncratic ways in which they respond to and implement mandated education policy - it is necessary to take account both of sociological and of ...
Alex Moore, Ball S., Ball S. J., Barbalet J., Billig M., Boler M., Bourdieu P., Bourdieu P., Britzman D., Codd J. A., Freud A., Freud S., Freud S., Fulcher G., Gallop J., Gewirtz S., Goodson I. F., Hartnett A., Kelly A. V., Klein M., Lacan J., Lacan J., Mitchell C., Moore A., Moore A., Moore A., Moore A., Moore A., Mulkay M., Smyth J., Thomas D., Wacquant L. J. D., Zizek S.   +32 more
core   +3 more sources

The structure of Polycomb-repressed chromatin in the bithorax complex [PDF]

Epigenetics & Chromatin, 2013
The 300 kb of the Drosophila bithorax complex (BX-C) is the original model for studying Hox gene repression by Polycomb group proteins. Decades of genetic experiments have led to the hypothesis that Polycomb organizes BX-C chromatin differently in each of the abdominal parasegments, and the structure of the chromatin is critical for maintaining cell ...
Bowman, Sarah K., Deaton, Aimee, Domingues, Heber, Bender, Welcome, Kingston, Robert   +4 more
openaire   +2 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

The state makes migration—and migration makes the state?

L’Année du Maghreb
This paper explores the relationship between migration politics and authoritarian regime consolidation in Tunisia, focusing on the period following President Kaïs Saïed’s coup in 2021.
Lorenzo Ghione
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Retinoblastoma makes its mark on imprinting in plants [PDF]

, 2008
Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Liliana M Costa, José F Gutierrez-Marcos, Wolf, Youngson, Spillane, Kermicle, Feil, Delaval, Bourc&apos, Schoenherr, Mager, Lewis, Gutierrez-Marcos, Kinoshita, Jullien, Choi, Morales-Ruiz, Reik, McCabe, Jung, Ebel, Hennig, Guitton, Ingouff, Jullien, Kimura, Rossi, Wu, Mathieu, Wu   +29 more
core   +2 more sources

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Cell, 1995
The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse
BARTSCH D, GHIRARDI, Mirella, SKEHEL P. A, KARL K. A, HERDER S, CHEN M, BAILEY C. H, KANDEL E. R.   +7 more
openaire   +3 more sources