Results 111 to 120 of about 92,184 (310)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

NoRC, a novel chromatin remodeling complex involved in ribosomal RNA gene silencing [PDF]

, 2004
Regulation of gene expression takes place in the nucleus in a highly structured and condensed nucleoprotein environment, called chromatin (Felsenfeld and Groudine, 2003; Khorasanizadeh, 2004; Vaquero et al., 2003).
Strohner, Ralf
core  

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

, 2011
Eukaryotic transcriptional repressors function by recruiting large coregulatory complexes that target histone deacetylase enzymes to gene promoters and enhancers.
Kampmann, Thorsten, Thorsten Kampmann, Louise Fairall, Jacquie A Greenwood, Schwabe, John W R, Peter J Watson, Neuhaus, David, Gooch, John T, Nagy, Laszlo, Watson, Peter J, John W R Schwabe, Benjamin T Goult, David Neuhaus, John T Gooch, Goult, Benjamin T, Zsolt Czimmerer, Jasmeen Oberoi, Czimmerer, Zsolt, Kallenberger, Bettina C, Bettina C Kallenberger, Fairall, Louise, Oberoi, Jasmeen, Ji-Chun Yang, Yang, Ji-Chun, Greenwood, Jacquie A, Laszlo Nagy   +25 more
core   +1 more source

Anarquistas de Ayer y de Hoy. De la identitad antifascista en la guerra civil española a la Memoria actual

Diacronie. Studi di Storia Contemporanea, 2011
The article starts from the idea that there is a common aspect between today and yesterday anarchism, which is its direct opposition to the “voluntary servitude” and the claim of freedom against any kind of authority and tyranny. The transmission of this
Carmen González Martínez es profesora de Historia Contemporánea en la Universidad de Murcia (España), ha dictado conferencias en Inglaterra, Francia, México, Chile, Cuba y Brasil. Su investigación responde a la doble perspectiva de la Historia Regional y la Historia Comparada. Este artículo profundiza en la línea de investigación abordada en Guerra Civil en Murcia. Un análisis sobre el Poder y los comportamientos colectivos (Murcia, 1999) y «El Frente Popular en España: de estrategia interclasista a su superación por la táctica de ‘tomar el cielo por asalto’» (Revista de Historia Social y de las Mentalidades, vol. 14, 2010, Chile). Ha sido coeditora del Dossier: Procesos de Construcción de la democracia en España y Chile (Ayer, nº 79, 3, 2010).
doaj  

Spatio-Temporal Regulation of Gibberellin Biosynthesis Contributes to Optimal Rhizome Bud Development

Rice
The perennial life cycle involves the reiterative development of sexual and asexual organs. Asexual structures such as rhizomes are found in various plant species, fostering extensive growth and competitive advantages.
Kanako Bessho-Uehara, Tomoki Omori, Stefan Reuscher, Keisuke Nagai, Ayumi Agata, Mikiko Kojima, Yumiko Takebayashi, Takamasa Suzuki, Hitoshi Sakakibara, Motoyuki Ashikari, Tokunori Hobo   +10 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

, 2009
Proteins of the GW182 family play an important role in the execution of microRNA repression in metazoa. They interact directly with Argonaute proteins, components of microRNPs, and also form part of P-bodies, structures implicated in translational ...
Filipowicz, Witold, Mathys, Hansruedi, Bhattacharyya, Sankar, Zipprich, Jakob T   +3 more
core   +1 more source

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression [PDF]

, 2017
Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival.
Kedersha, Nancy, Lyons, Shawn, Anderson, Paul, Ivanov, Pavel, Achorn, Chris   +4 more
core   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

The role of polyhomeotic in polycomb group-mediated regulation of the tumour suppressor P16INK4A

, 2010
The INK4A tumour suppressor gene is negatively regulated by the Polycomb Group (PcG) complexes, which plays an important role in stem cell- and cancer biology.
de Breed, L.A.
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