Results 221 to 230 of about 30,587 (268)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1. [PDF]

Nat Struct Mol Biol
Ciapponi M, Cafiso M, Schkölziger S, Benda C, Bonnet J, Müller J.   +5 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Pilot report of an anti-PD-1/VEGF bispecific antibody for treating recurrent H3K27M-mutant diffuse midline gliomas. [PDF]

Cancer Immunol Immunother
Yanchu L, Hongbin W, Xiaoli Y, Li Z, Jun W, Meiling R, Xiaoyan Y, Lei L, Feng W.   +8 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Hiding in Plain Sight: HIV-1 Membraneless Organelles as Nuclear Hubs-Host Hijacking, Replication, Immune Evasion, and Drug-Access Implications. [PDF]

Pathogens
Broccolo F, Sannino A, Pollini M, Paladini F, Mourer T, Di Nunzio F.   +5 more
europepmc   +1 more source

Structural Basis of PPARγ-Mediated Transcriptional Repression by the Covalent Inverse Agonist FX-909. [PDF]

J Med Chem
Laughlin ZT, Arifova L, Munoz-Tello P, Yu X, Giridhar MNK, Dong J, Harp JM, Zhu D, Kamenecka TM, Kojetin DJ.   +9 more
europepmc   +1 more source

Epigenetic and chromatin remodeling mechanisms across cardiomyopathies: a comprehensive review. [PDF]

Epigenetics Chromatin
Upadhyaya P.
europepmc   +1 more source

Revealing G4 Structures as Drug Targets: Exploring the Potential of Novel Therapeutic Agents. [PDF]

Research (Wash D C)
Che Y, Peng Y, Pan X, Hu X, Zhao Y, Zhao Y, Tian C, Yuan M, Yin Y, Gan R, Li Y, Pei Z, Liu S, Li Z, Dong H, Tan Y, Sun G, Wu H, Wei M.   +18 more
europepmc   +1 more source