Results 171 to 180 of about 2,089,944 (391)
Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda +12 morewiley +1 more sourceReproducibility of Mydriasis
Ophthalmic Research, 1992 A combination of a single drop of each of 0.5% tropicamide and of 10% phenylephrine hydrochloride instilled after routine applanation tonometry gave consistent pupil dilatation in a population with cataract studied over 5 years. The dilatation allows reproducible photographic documentation of cataracts in long-term studies.openaire +3 more sourcesLandscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno +5 morewiley +1 more sourceData‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo +8 morewiley +1 more sourceEstimating the reproducibility of psychological science
Science, 2015 Alexander A. Aarts, Joanna E. Anderson, Christopher J. Anderson, Peter Raymond Attridge, A. Attwood, Jordan R. Axt, Molly Babel, Š. Bahník, E. Baranski, M. Barnett-Cowan, E. Bartmess, Jennifer S. Beer, Raoul Bell, Heather Bentley, Leah Beyan, Grace Binion, D. Borsboom, Annick Bosch, Frank Bosco, Sara D. Bowman, M. Brandt, E. L. Braswell, Hilmar Brohmer, B. T. Brown, Kristina Brown, Jovita Brüning, Ann Calhoun-Sauls, Shannon P. Callahan, E. Chagnon, Jesse J. Chandler, Christopher R. Chartier, F. Cheung, Cody Daniel Christopherson, Linda Cillessen, R. Clay, Hayley M. D. Cleary, M. Cloud, Michael Conn, J. Cohoon, Simon Columbus, A. Cordes, G. Costantini, Leslie D Cramblet Alvarez, E. Cremata, J. Crusius, J. DeCoster, M. DeGaetano, Nicolás Delia Penna, Bobby Den Bezemer, M. Deserno, Olivia Devitt, L. Dewitte, David G. Dobolyi, Geneva T. Dodson, M. Donnellan, Ryan Donohue, Rebecca A. Dore, A. Dorrough, Anna Dreber, M. Dugas, Elizabeth W. Dunn, Kayleigh E. Easey, Sylvia Eboigbe, Casey M Eggleston, Jo Embley, S. Epskamp, Timothy M. Errington, Vivien Estel, Frank J. Farach, J. Feather, A. Fedor, Belén Fernández-Castilla, Susann Fiedler, James G. Field, Stanka A. Fitneva, Taru Flagan, Amanda L. Forest, Eskil Forsell, J. D. Foster, Michael C. Frank, Rebecca S. Frazier, Heather M. Fuchs, P. Gable, Jeff Galak, E. Galliani, Anup Gampa, Sara Garcia, Douglas Gazarian, E. Gilbert, Roger Giner-Sorolla, A. Glöckner, Lars Goellner, Jin X. Goh, R. Goldberg, Patrick T. Goodbourn, S. Gordon-McKeon, Bryan H. Gorges, Jessie Gorges, J. Goss, J. Graham, J. Grange, J. Gray, C.H.J. Hartgerink, Joshua K. Hartshorne, F. Hasselman, Timothy Hayes, Emma Heikensten, Felix Henninger, J. Hodsoll, Taylor Holubar, G. Hoogendoorn, D. Humphries, C. O. Hung, N. Immelman, Vanessa C. Irsik, G. Jahn, F. Jäkel, Marc Jekel, M. Johannesson, L. Johnson, David J. Johnson, Kate M. Johnson, William Johnston, K. Jonas, Jennifer A. Joy-Gaba, H. Kappes, Kim Kelso, Mallory C. Kidwell, Seung K. Kim, M. Kirkhart, Bennett Kleinberg, G. Knežević, F. Kolorz, J. Kossakowski, R. Krause, J.M.T. Krijnen, T. Kuhlmann, Y. Kunkels, Megan M. Kyc, Calvin K. Lai, Aamir Laique, D. Lakens, Kristin A. Lane, Bethany Lassetter, L. Lazarević, E. Bel, Key Jung Lee, Minha Lee, K. Lemm, C. Levitan, Melissa Lewis, Lin Lin, Stephanie C. Lin, Matthias Lippold, Darren Loureiro, Ilse Luteijn, S. Mackinnon, Heather N. Mainard, Denise C. Marigold, D. P. Martin, Tylar Martinez, E. Masicampo, Joshua J. Matacotta, Maya B. Mathur, Michael May, Nicole C Mechin, Pranjal H. Mehta, Johannes M. Meixner, Alissa Melinger, Jeremy K. Miller, Mallorie Miller, K. Moore, Marcus Möschl, Matt Motyl, S. Muller, M. Munafo, K. Neijenhuijs, Taylor Nervi, Gandalf Nicolas, G. Nilsonne, Brian A. Nosek, Michèle B. Nuijten, Catherine Olsson, C. Osborne, Lutz Ostkamp, M. Pavel, I. Penton-Voak, O. Perna, C. Pernet, M. Perugini, R. Pipitone, M. Pitts, F. Plessow, J. Prenoveau, R. Rahal, Kate A. Ratliff, David A. Reinhard, Frank Renkewitz, Ashley A. Ricker, A. Rigney, Andrew M Rivers, Mark A. Roebke, Abraham M. Rutchick, Robert S. Ryan, O. Şahin, Anondah Saide, Gillian M. Sandstrom, David Santos, R. Saxe, René Schlegelmilch, Kathleen Schmidt, Sabine Scholz, L. Seibel, Dylan Selterman, S. Shaki, W. B. Simpson, H. Sinclair, Jeanine L. M. Skorinko, A. Slowik, J. Snyder, C. Soderberg, Carina M. Sonnleitner, N. Spencer, Jeffrey R. Spies, S. Steegen, S. Stieger, Nina Strohminger, G. Sullivan, Thomas Talhelm, M. Tapia, A. T. Dorsthorst, M. Thomae, Sarah L. Thomas, Pia Tio, Frits Traets, Steve Tsang, F. Tuerlinckx, Paul Turchan, Milan Valášek, A. V. Veer, R. V. Aert, M. V. Assen, R. V. Bork, Mathijs van de Ven, D. V. D. Bergh, M. Hulst, R. V. Dooren, J. Doorn, D. V. Renswoude, H. Rijn, Wolf Vanpaemel, Alejandro Echeverría, Melissa Vazquez, Natalia Vélez, Marieke Vermue, M. Verschoor, M. Vianello, M. Voracek, Gina Vuu, E. Wagenmakers, Joanneke Weerdmeester, A. Welsh, Erin C. Westgate, Joeri Wissink, M. Wood, A. Woods, Emily M. Wright, Sining Wu, M. Zeelenberg, Kellylynn Zuni +269 moresemanticscholar +1 more sourceThe anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu +10 morewiley +1 more sourceDose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin +10 morewiley +1 more source
