Results 51 to 60 of about 115,296 (125)

Modeles De Croissance Fractale : Epidemies, Evolutions En Biologie, Ecologie, Trafic, Economie [PDF]

arXiv, 2004
Several simple growth and decay models use concepts and measures from fractal geometry. Kinetic models relevant to condensed matter observations arerecalled. They should be specifically adapted with appropriate degrees of freedom in order to reproduce power law behaviors, e.g. of species extinctions, cloud fracture, financial crashes.
arxiv  

MOLNs: A cloud platform for interactive, reproducible and scalable spatial stochastic computational experiments in systems biology using PyURDME [PDF]

arXiv, 2015
Computational experiments using spatial stochastic simulations have led to important new biological insights, but they require specialized tools, a complex software stack, as well as large and scalable compute and data analysis resources due to the large computational cost associated with Monte Carlo computational workflows.
arxiv  

The challenges of replication

eLife, 2017
Interpreting the first results from the Reproducibility Project: Cancer Biology requires a highly nuanced approach.

semanticscholar   +1 more source

Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

eLife, 2017
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015) that described how we intended to replicate selected experiments from the paper "BET bromodomain inhibition as a therapeutic strategy
F. Aird, I. Kandela, Christine Mantis, Elizabeth Alexandria Stephen R Nicole Timothy M Iorns Denis Williams Perfito Errington   +3 more
semanticscholar   +1 more source

Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

eLife, 2018
As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Blum et al., 2015), that described how we intended to replicate selected experiments from the paper ‘Transcriptional amplification in tumor cells with elevated c ...
L. M. Lewis, M. C. Edwards, Zachary R. Meyers, C. Talbot, Haiping Hao, David L. Blum, Elizabeth Rachel Alexandria Nicole Timothy M Iorns Tsui Denis Perfito Errington, Elizabeth Iorns, Rachel Tsui, Alexandria Denis, N. Perfito, Timothy M. Errington   +11 more
semanticscholar   +1 more source

Registered report: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

eLife, 2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
J. Repass, Nimet Maherali, Kate Owen, Elizabeth William Fraser Joelle Nicole Timothy Iorns Gunn Tan Lomax Perfito Errington   +3 more
semanticscholar   +1 more source

Folding@Home and Genome@Home: Using distributed computing to tackle previously intractable problems in computational biology [PDF]

arXiv, 2009
For decades, researchers have been applying computer simulation to address problems in biology. However, many of these "grand challenges" in computational biology, such as simulating how proteins fold, remained unsolved due to their great complexity. Indeed, even to simulate the fastest folding protein would require decades on the fastest modern CPUs ...
arxiv  

Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

eLife, 2017
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2014) that described how we intended to replicate selected experiments from the paper "Melanoma genome sequencing reveals frequent ...
S. Horrigan, Pascal Courville, Darryl Sampey, F. Zhou, Steve Cai, Elizabeth Alexandria Stephen R Nicole Timothy M Iorns Denis Williams Perfito Errington   +5 more
semanticscholar   +1 more source

Cellular Automata Model of Macroevolution [PDF]

Proceedings of the Fourteenth National Conference on Application of Mathematics in Biology and Medicine (pp. 18-25), Uniwersytet Warszawski, QPrint Warszawa 2008, ISBN:83-903893-4-7, 2009
In this paper I describe a cellular automaton model of a multi-species ecosystem, suitable for the study of emergent properties of macroevolution. Unlike majority of ecological models, the number of coexisting species is not fixed. Starting from one common ancestor they appear by "mutations" of existent species, and then survive or extinct depending on
arxiv  

In Pursuit of Total Reproducibility [PDF]

arXiv
The vast majority of scientific contributions in the field of computational systems biology are based on mathematical models. These models can be broadly classified as either dynamic (kinetic) models or steady-state (constraint-based) models. They are often described in specific markup languages whose purpose is to aid in the distribution and ...
arxiv