Results 171 to 180 of about 418,446 (282)

Towards reproducible research

, 2019
For a researcher, there is nothing more frustrating than the failure to reproduce major results obtained a few months back. The causes of such disappointments can be multiple and insidious. This phenomenon plays an important role in the so-called “research reproducibility crisis”.This book takes a current perspective onto a number of potentially ...
Desquilbet, Loic, Granger, Sabrina, Hejblum, Boris, Legrand, Arnaud, Pernot, Pascal, Rougier, Nicolas, de Castro Guerra, Elisa, Courbin-Coulaud, Martine, Duvaux, Ludovic, Gravier, Pierre, Le Campion, Grégoire, Roux, Solenne, Santos, Frédéric   +12 more
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

OpenSAFELY: A platform for analysing electronic health records designed for reproducible research. [PDF]

Pharmacoepidemiol Drug Saf
Nab L, Schaffer AL, Hulme W, DeVito NJ, Dillingham I, Wiedemann M, Andrews CD, Curtis H, Fisher L, Green A, Massey J, Walters CE, Higgins R, Cunningham C, Morley J, Mehrkar A, Hart L, Davy S, Evans D, Hickman G, Inglesby P, Morton CE, Smith RM, Ward T, O'Dwyer T, Maude S, Bridges L, Butler-Cole BFC, Stables CL, Stokes P, Bates C, Cockburn J, Hester F, Parry J, Bhaskaran K, Schultze A, Rentsch CT, Mathur R, Tomlinson LA, Williamson EJ, Smeeth L, Walker A, Bacon S, MacKenna B, Goldacre B.   +44 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Reproducible Research Practices in Magnetic Resonance Neuroimaging: A Review Informed by Advanced Language Models. [PDF]

Magn Reson Med Sci
Karakuzu A, Boudreau M, Stikov N.
europepmc   +1 more source

nicheCore: Core infrastructure for reproducible consumer psychology research in R

Josh Gonzales
openalex   +1 more source

Leveraging Large Language Models for InteractiveExploration of MRI Research Reproducibility: A Self-EvolvingReview [PDF]

Agâh Karakuzu, Mathieu Boudreau, Nikola Stikov   +2 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

REPRODUCIBLE RESEARCH WORKFLOW IN R FOR THE ANALYSIS OF PERSONALIZED HUMAN MICROBIOME DATA

, 2015
Benjamin J. Callahan, Diana M. Proctor, David A. Relman, Julia Fukuyama, Susan Holmes   +4 more
openalex   +1 more source