Results 171 to 180 of about 871,682 (287)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Replicability and Reproducibility in Comparative Psychology

Frontiers in Psychology, 2017
Jeffrey R. Stevens
doaj   +1 more source

More efficient reproducible research in hydrology: moving research down the academic career scale (MRDTACS). [PDF]

Philos Trans A Math Phys Eng Sci
Hut R, Hall C.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Balancing ethical data sharing and open science for reproducible research in biomedical data science. [PDF]

Cell Rep Med
Lvovs D, Creason AL, Levine SS, Noble M, Mahurkar A, White O, Fertig EJ.   +6 more
europepmc   +1 more source

Towards reproducible research

, 2019
For a researcher, there is nothing more frustrating than the failure to reproduce major results obtained a few months back. The causes of such disappointments can be multiple and insidious. This phenomenon plays an important role in the so-called “research reproducibility crisis”.This book takes a current perspective onto a number of potentially ...
Desquilbet, Loic, Granger, Sabrina, Hejblum, Boris, Legrand, Arnaud, Pernot, Pascal, Rougier, Nicolas, de Castro Guerra, Elisa, Courbin-Coulaud, Martine, Duvaux, Ludovic, Gravier, Pierre, Le Campion, Grégoire, Roux, Solenne, Santos, Frédéric   +12 more
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Meta-analytical approaches to ordinal outcome data in clinical interventional studies: A scoping review with reproducible research. [PDF]

PLoS One
Mulhem A.
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

OpenSAFELY: A platform for analysing electronic health records designed for reproducible research. [PDF]

Pharmacoepidemiol Drug Saf
Nab L, Schaffer AL, Hulme W, DeVito NJ, Dillingham I, Wiedemann M, Andrews CD, Curtis H, Fisher L, Green A, Massey J, Walters CE, Higgins R, Cunningham C, Morley J, Mehrkar A, Hart L, Davy S, Evans D, Hickman G, Inglesby P, Morton CE, Smith RM, Ward T, O'Dwyer T, Maude S, Bridges L, Butler-Cole BFC, Stables CL, Stokes P, Bates C, Cockburn J, Hester F, Parry J, Bhaskaran K, Schultze A, Rentsch CT, Mathur R, Tomlinson LA, Williamson EJ, Smeeth L, Walker A, Bacon S, MacKenna B, Goldacre B.   +44 more
europepmc   +1 more source