Design, Synthesis, and Evaluation of New 1,4‐Naphthoquinone‐1,2,3‐triazoles as Antimalarial Agents
Compound 9g, a 1,4‐naphthoquinone‐1,2,3‐triazole derivative, exhibited potent activity against P. falciparum 3D7 and in silico analysis revealed strong interactions with 1J3 and 1LDG targets, while MD simulations confirmed the stability of the ligand‐3FGO complex.
Lina Rezainia +13 more
wiley +1 more source
Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley +1 more source
Modified meiosis in the tardigrade Hypsibius exemplaris maintains heterozygosity across the genome. [PDF]
Coke AN +4 more
europepmc +1 more source
Environmental and Evolutionary Correlates of Extinction Risk in a Global Biodiversity Hotspot
We show that larger genera have a greater number of threatened and near‐threatened species, and that extinction risk is uncoupled with evolutionary history (diversification, speciation, extinction rates and lineage age). The decoupling of diversification rates and lineage age with current extinction risk suggests drivers of extinction risk are ...
Francis J. Nge, Thi H. Chung
wiley +1 more source
Mutation accumulation in a hybrid parthenogenetic vertebrate. [PDF]
Müller ZL +6 more
europepmc +1 more source
In this study, we conducted investigations and monitoring on lakes during the wet season and dry season. We studied the structure, taxonomic/functional diversity, community assembly, and niche differentiation of plankton communities, analyzed the biogeographical patterns of plankton communities, and explored the driving factors affecting plankton ...
Lingli Jiang +6 more
wiley +1 more source
When growth becomes risky: stress-driven sporulation and sexual development in fungi. [PDF]
Yang J, Wang Q, Liu H.
europepmc +1 more source
The Origin and the Adaptive Function of Genetic Recombination in Sexual Reproduction. [PDF]
Bernstein C, Bernstein H.
europepmc +1 more source
This study demonstrates that phenotypic integration, the coordinated covariation among traits, is itself a plastic and context‐dependent property in clonal Daphnia. Contrary to the classic constraint model, we found that stronger integration can facilitate greater plasticity, particularly under low‐food conditions, with differential plasticity between ...
Xiaofei Tian, Wenping Feng, Xiumei Zhang
wiley +1 more source
Stepwise emergence of recombination suppression precedes fissiparous asexuality in the planarian Schmidtea mediterranea. [PDF]
Brand JN +8 more
europepmc +1 more source

