Results 141 to 150 of about 2,627,557 (281)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
MathematicsAround the world, the people are simultaneously susceptible to or infected with several infections. This work aims at the analysis of the dynamics of transmission of two deadly viruses, COVID-19 and Influenza, using a co-infection epidemiological model ...
Annamalai Meenakshi +3 more
doaj +1 more source
The effective reproduction number: Convexity, concavity and invariance
Journal of the European Mathematical SocietyMotivated by the question of optimal vaccine allocation strategies in heterogeneous population for epidemic models, we study various properties of the effective reproduction number . In the simplest case, given a fixed non-negative matrix K , this corresponds ...
Delmas, Jean-François +2 more
openaire +2 more sources
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Improving adherence to a daily PrEP regimen is key when considering long-time partnerships
Journal of Biological DynamicsA population model of HIV that includes susceptible individuals not taking the pre-exposure prophylaxis (PrEP), susceptible individuals taking daily PrEP, and infected individuals is developed for casual partnerships, as well as monogamous and non ...
S. J. Gutowska +2 more
doaj +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Robust uncertainty quantification in popular estimators of the instantaneous reproduction number. [PDF]
Am J EpidemiolSteyn N, Parag KV.
europepmc +2 more sources