Results 51 to 60 of about 1,281 (216)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Variation in Eusperm Length May Reflect Reproductive Barriers and Differences in Sperm Competition Intensity Among Littorina Snails

Ecology and Evolution
Reproductive barriers limit gene flow and drive population divergence. Sperm morphology plays an important role in reproductive barriers, as successful fertilization depends on how well sperm perform in the female environment.
Luisa Kumpitsch, Kerstin Johannesson, Jonathan N. Havenhand, Erica H. Leder   +3 more
doaj   +1 more source

Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review

Frontiers in Cell and Developmental Biology
The gut microbiota, comprising trillions of bacteria, fungi, and viruses, exists in symbiosis with the host. As the largest microbial ecosystem in the human body.
Lulu Fu, Min Wang, Dan Li, Shuai Ma, Fuliang Zhang, Lianwen Zheng   +5 more
doaj   +1 more source

Experience of anti-adhesion barrier in the complex therapy of patients with uterine factor infertility [PDF]

РМЖ. Мать и дитя, 2023
N.I. Nasyrova1,2, Yu.E. Dobrokhotova2, L.A. Ozolinya2, M.Z. Argun1, K.V. Mirskaya1 1Central Clinical Hospital of Civil Aviation, Moscow, Russian Federation 2Pirogov Russian National Research Medical University, Moscow, Russian Federation Aim:
N.I. Nasyrova, Yu.E. Dobrokhotova, L.A. Ozolinya, M.Z. Argun, K.V. Mirskaya   +4 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Mating Patterns and Postzygotic Barriers in a Hybrid Swarm of Two Closely Related Pigeon Species

Ecology and Evolution
Hybrid zones provide a valuable framework for understanding evolutionary pathways. We investigated mating patterns and reproductive barriers using captive individuals derived from a natural hybrid swarm between hill pigeons (Columba rupestris) and feral ...
Jin‐yong Kim, Seung‐Gu Kang, Jongmin Yoon   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source