Results 161 to 170 of about 2,793,995 (298)

The potential roles of androgen and estrogen receptors during reproductive cycle in Pampus argenteus. [PDF]

PLoS One
Wan Z, Ding M, Zhang X, Li C, Zou J, Wang D, Wang X, Guo C.   +7 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Developmental timing in the female reproductive cycle of Araucaria araucana: seasonality and evolutionary perspectives. [PDF]

Ann Bot
Emprin VL, Gleiser G, San Martín JAB, Reutemann AG, Speziale KL, Calviño CI, Pozner RE.   +6 more
europepmc   +1 more source

Combined Preimplantation Genetic Testing for Genetic Kidney Disease: Genetic Risk Identification, Assisted Reproductive Cycle, and Pregnancy Outcome Analysis. [PDF]

Front Med (Lausanne), 2022
Xiao M, Shi H, Rao J, Xi Y, Zhang S, Wu J, Zhu S, Zhou J, Xu H, Lei C, Sun X.   +10 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Gene Expression and Alternative Splicing Throughout the Reproductive Cycle of a Viviparous Lizard Reveal Novel Genes for Pregnancy and Convergence With Squamates and Mammals. [PDF]

Mol Ecol
Smout JL, Bain MM, McLaughlin M, Elmer KR.   +3 more
europepmc   +1 more source

Life-history attributes of Arctic-breeding birds drive uneven responses to environmental variability across different phases of the reproductive cycle. [PDF]

Ecol Evol, 2021
Ruthrauff DR, Patil VP, Hupp JW, Ward DH.   +3 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Circulating microRNAs reveal egg-brain crosstalk and a brain-predominant microRNA linked to the onset of the next reproductive cycle in iteroparous salmonids. [PDF]

BMC Biol
Roza de Abreu M, Cardona E, Lagarde C, Milhade L, Yoshizaki G, Thermes V, Bobe J.   +6 more
europepmc   +1 more source

Reproductive Cycles and Factors Influencing Reproductive Cycle in Finfish and Their Application for Aquaculture

Fish and shellfish have intricate reproduction cycles that are impacted by a variety of biological and environmental variables. Among the several reproductive techniques used by finfish, especially teleosts, is external fertilization, in which sperm fertilize eggs released into the water column.
openaire   +2 more sources