Results 61 to 70 of about 5,086,794 (310)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Experiences of drought, heavy rains, and flooding and linkages with refugee youth sexual and reproductive health in a humanitarian setting in Uganda: qualitative insights

Global Public Health
Climate-related extreme weather events (EWE) exacerbate resource insecurities that, in turn, shape sexual and reproductive health (SRH). Refugee settlements face increased EWE exposure yet are understudied in EWE research.
C. H. Logie, M. Loutet, F. MacKenzie, M. Okumu, R. Leggett, F. S. Akinwande, S. Odong Lukone, N. Kisubi, P. Kyambadde, L. Otika, M. Lukwago, M. Narasimhan   +11 more
doaj   +1 more source

Tracking official development assistance for reproductive health in conflict-affected countries. [PDF]

, 2009
BACKGROUND: Reproductive health needs are particularly acute in countries affected by armed conflict. Reliable information on aid investment for reproductive health in these countries is essential for improving the efficiency and effectiveness of aid ...
Guy Samantha, Roberts Bayard, Guy, S., Roberts, Bayard, Samantha Guy, Conteh, L., Conteh Lesong, Bayard Roberts, Louise Lee-Jones, Patel, Preeti; id_orcid, Roberts, B., Guy, Samantha, Lee-Jones, L., Lee-Jones Louise, Patel, Preeti, Lee-Jones, Louise, Preeti Patel, Lesong Conteh, Patel, P., Conteh, Lesong, Patel Preeti   +20 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Psychosocial stressors related to extreme weather events and multiple resource insecurities: qualitative insights from refugee youth in an Ugandan humanitarian setting

SSM - Mental Health
Extreme weather events (EWE) contribute to heightened psychosocial stressors through complex pathways, including by worsening resource insecurities.
Carmen H. Logie, Ofir Sivan, Rachel Leggett, Moses Okumu, Miranda Loutet, Frannie MacKenzie, Simon Odong Lukone, Nelson Kisubi, Lesley Gittings, Peter Kyambadde, Caetano Dorea, Manjulaa Narasimhan   +11 more
doaj   +1 more source

Kesehatan Reproduksi Remaja Putri di Pondok Pesantren Sidoarjo Jawa Timur

Majalah Kedokteran Bandung, 2015
Reproductive organ maturation process in adolescence is often prone to health issues. Adolescents spend more time in school, especially when they study in an islamic boarding school.
Queen Khoirun Nisa Mairo, Sri Endah Rahayuningsih, Benny Hasan Purwara   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Social and biological determinants of reproductive success in Swedish males and females born 1915–1929 [PDF]

, 2009
Studying biological and social determinants of mortality and fertility provides insight into selective pressures in a population and the possibility of trade-offs between short- and long-term reproductive success.
Goodman, Anna, Koupil, I, Goodman, A, Koupil, Ilona,, Koupil, Ilona   +4 more
core   +1 more source