Results 111 to 120 of about 2,415,924 (290)

Single-cell RNA sequencing of leukocytes at the maternal-fetal interface in physiological and pathological Nodal-deficient pregnancies

Frontiers in Immunology
Leukocytes at the maternal-fetal interface have critical functions during pregnancy in the prevention of maternal reactivity towards fetal alloantigens, suppression of excess inflammation and promotion of placental angiogenesis.
Sarah Yull, Sarah Yull, Alain Pacis, Alain Pacis, Laura Girardet, Laura Girardet, Daniel Dufort, Daniel Dufort, Daniel Dufort   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Hatching asynchrony as a reproductive strategy in birds may explain the hatching failure of the last eggs of the clutch

Hatching failure, due to infertility or embryo mortality, is an important factor contributing to reduced reproductive success in birds. Although hatching failure and its possible causes have been widely investigated, the stage of development at which ...
Baldan, David, Fuertes Recuero, Manuel, Cantarero Carmona, Alejandro   +2 more
core   +1 more source

Extreme Reproductive Constraints Under Pollinator Scarcity in the Endangered Orchid Calanthe aristulifera: Five-Year Preliminary Monitoring in South Korea

Diversity
Calanthe aristulifera is an endangered terrestrial orchid that has historically suffered from severe illegal poaching. However, little is understood regarding population dynamics for remaining C. aristulifera populations.
Seongjun Kim, Chang Woo Lee, Jung Eun Hwang, Hwan-Joon Park, Hyeong Bin Park, Young-Joong Kim, Yubin Lee   +6 more
doaj   +1 more source

Autoimmune disorders and reproductive failure [PDF]

Human Reproduction, 1996
M, Royburt, I, Yron, B, Fisch
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Hysteroscopic hysteroplasty for the treatment of T-shaped uteri in women with reproductive failure. [PDF]

Front Med (Lausanne), 2023
Ying L, Li Z, Shangping D, Tong Z, Liguo L, Qiaoli T.   +5 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source