Results 291 to 300 of about 1,046,081 (384)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Female reproductive health trends and autism spectrum disorder prevalence between 2000 and 2024. [PDF]

Sci Rep
Al-Salihy AAS.
europepmc   +1 more source

Critical Windows of Exposure for Children's Health: The Reproductive System in Animals and Humans

, 2000
Jon L. Pryor, Claude L. Hughes, Warren G. Foster, Barbara F. Hales, Bernard Robaire   +4 more
openalex   +1 more source

How prepared are young, rural women in India to address their sexual and reproductive health needs? a cross-sectional assessment of youth in Jharkhand [PDF]

A Malhotra, Amit Rawat, Bimla Upadhyay, EE Daniel, International Institute for Population Sciences, International Institute for Population Sciences, Janardan Warvadekar, JR Chromy, K Malleshappal, Kathryn L. Andersen, KG Santhya, L Kish, LB Finer, M Alexander, Ministry of Health and Family Welfare, Ministry of Rural Development, Ministry of Women and Child Development, Ministry of Youth Affairs and Sports, N Kabeer, National Institute of Medical Statistics, Office of Register General India, P Kothari, Paramita Aich, RY Aras, S Parwej, SJ Jejeebhoy, SJ Jejeebhoy, SJ Jejeebhoy, SK Banerjee, SK Banerjee, SK Banerjee, SK Banerjee, Sushanta K. Banerjee, World Health Organization, World Health Organization   +34 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Abortion care process based on sexual and reproductive health and rights in Japan: A qualitative study. [PDF]

Jpn J Nurs Sci
Sato Y, Haga A, Tokutake C, Samejima A, Kanai M, Nakagomi S.   +5 more
europepmc   +1 more source

Male reproductive health: cause for concern?

, 2000
D. Stewart Irvine
openalex   +1 more source

Graphical displays for effective reporting of evidence quality tables in research syntheses [PDF]

CE Fox, CL Wong, D Atkins, DT Bauer, Ekaterina Mishanina, HJ Schunemann, ICF Barbosa, J Marjoribanks, J Nixon, JP Daniels, JP Daniels, Khalid S. Khan, KJ McCaffery, KS Khan, KS Khan, Luciano Mignini, MI Nor Azlin, NT Brewer, P Vercellini, Rita Champaneria, S Daniels, S Daniels, ST Hawley   +22 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source