Results 31 to 40 of about 418,862 (310)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case–control study

Environmental Health, 2021
Background Prenatal exposure to heavy metals is implicated in the etiology of birth defects. We investigated whether concentrations of cadmium (Cd) and lead (Pb) in umbilical cord tissue are associated with risk for neural tube defects (NTDs) and whether
Mengyuan Liu, Jinhui Yu, Zaiming Su, Ying Sun, Yaqiong Liu, Qing Xie, Zhiwen Li, Linlin Wang, Jie Zhang, Lei Jin, Aiguo Ren   +10 more
doaj   +1 more source

Progesterone Resistance in Endometriosis

European Medical Journal Reproductive Health, 2022
Endometriosis is characterised by the presence of endometrium-like tissue on the pelvis and other organs. Progesterone resistance due to suppressed progesterone receptor (PGR) expression and action is a general feature of endometriosis and is a cause of
Jeevitha Poorasamy, Jayasree Sengupta, Asmita Patil, Debabrata Ghosh   +3 more
doaj   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Reproductive health research challenges [PDF]

Reproductive Health, 2004
Welcome to the journal Reproductive Health. The Journal adopts the broad definition of reproductive health as endorsed by the International Conference on Population and Development in Cairo in 1994. Reproductive health is defined as a state of physical mental and social well-being in all matters relating to the reproductive system at all stages of life.
Regina Kulier, Aldo Campana
openaire   +3 more sources

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Monozygotic Pregnancies Following Assisted Reproductive Technology: A Review

European Medical Journal Reproductive Health, 2016
Introduction: Assisted reproductive technology (ART) is associated with an increased risk of monozygotic twinning. This narrative review attempts to summarise the known literature regarding the aetiology, incidence, risk factors, diagnosis, and prognosis
Mariano Mascarenhas, Keerthi Gnanaprabha
doaj  

The impact of facility audits, evaluation reports and incentives on motivation and supply management among family planning service providers: an interventional study in two districts in Maputo Province, Mozambique

BMC Health Services Research, 2017
Backrgound Good progress is being made towards universal access to contraceptives, however stock-outs still jeopardize progress. A seldom considered but important building block in optimizing supply management is the degree to which health workers feel ...
Heleen Vermandere, Anna Galle, Sally Griffin, Málica de Melo, Lino Machaieie, Dirk Van Braeckel, Olivier Degomme   +6 more
doaj   +1 more source

Intersection of HIV and Reproductive Health [PDF]

AIDS Research and Treatment, 2013
The HIV epidemic is integrally linked to reproductive health. Indeed HIV itself, which is predominantly a sexually transmitted infection, is a key reproductive health issue. In women, HIV can have adverse impact on pregnancy, childbirth, and breastfeeding. HIV status also affects conception and parenting choices.
Helen Rees, Craig R. Cohen, Kelly Blanchard, Elizabeth A. Bukusi   +3 more
openaire   +4 more sources

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source