Results 91 to 100 of about 416,423 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Clinical and immunological characteristics of women with infertility and/or a history of recurrent pregnancy loss

Акушерство, гинекология и репродукция
Aim: to conduct a comprehensive analysis of clinical, anamnestic and immunological characteristics of women with infertility and/or a history of recurrent pregnancy loss.Materials and Methods.
A. G. Burduli, N. K. Tetruashvili, I. P. Balmasova, A. E. Donnikov, R. V. Krasheninnikova, E. A. Kalinina   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Author’s Keywords Index

Gynecology Obstetrics & Reproductive Medicine, 2021
Gynecology Obstetrics and Reproductive Medicine
doaj  

Three Decades of Ovarian Tissue Cryopreservation in Western Sweden: Indications, Techniques, and Reproductive Outcomes in a Regional Program

Reproductive Medicine
Introduction: Ovarian tissue cryopreservation (OTC) has emerged as an important fertility preservation option for women and girls at risk of treatment-induced ovarian failure.
Judy Bittar, Mattias Akouri, Jynfiaf Francis, Panagiotis Tsiartas, Randa Akouri   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

La préservation de fertilité des personnes trans en France : trajectoire morale d’une pratique médicale

Genre, Sexualité et Société
In recent years, the issue of reproductive rights for trans individuals has gained significant visibility in France, compelling professionals in reproductive medicine to confront demands that challenge the binary and cisheteronormative paradigm ...
Marie Mesnil, Sylvie Morel
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Descriptive analysis of immunological abnormalities in recurrent reproductive failure and therapeutical outcomes

Medwave
Introduction Reproductive immunology has advanced significantly, recognizing the immune system as crucial in pregnancy development and facilitating the identification of abnormalities causing recurrent reproductive failure, as well as proposing targeted ...
Eduardo de la Fuente-Muñoz, Nabil Subhi-Issa, Ángela Villegas Mendiola, Juliana Ochoa-Grullón, Kissy Guevara-Hoyer, Raquel Gil-Laborda, Lydia Pilar-Suárez, María Dolores Mansilla Ruíz, María Pilar Gasca Escorial, Teresa Gastañaga-Holguera, Marta Calvo Urrutia, María Guzmán Fulgencio, Natalia Rodríguez Vicente, Miguel Fernández-Arquero, Ignacio Cristóbal García, Silvia Sánchez-Ramón   +15 more
doaj   +1 more source