Results 91 to 100 of about 1,320 (216)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Higher locomotor costs of pregnancy in viviparous compared to oviparous common lizards (Zootoca vivipara)

Ecology and Evolution
Pregnancy is a physiological cost of reproduction for animals that rely on fleeing to avoid predators. Costs of reproduction are predicted to differ between alternative reproductive strategies or modes, such as egg‐laying (oviparity) or live‐bearing ...
Robert Hussain, Hans Recknagel, Kathryn R. Elmer   +2 more
doaj   +1 more source

The Change of the Mode of Reproduction in Japan

Contemporary Sociological Studies, 2001
わが国の階級・階層構造の再生産のあり方は,二元的再生産様式,一元的再生産様式,多元的再生産様式という形で段階的に変化してきた。第二次大戦前には,二元的な再生産様式のもとで労働者・農民と資本家・地主という身分的な性格をともなう階級・階層構造が複線型の教育体系を通して再生産されていた。戦後,教育体系が単線化されることにより,ヒエラルヒー的な一元的再生産様式の基礎が作られた。しかし,一元的な機構的システムが完成するのは,六大企業集団を中心とする一元的機構的システムが構築され,生活水準が向上した高度経済成長期に入ってからであった。その後,オイルショックを契機に低成長期へ移行したが,一元的再生産様式は解体されず,むしろ成熟した形をとり,階級・階層の世代的再生産の傾向が強まった。しかし ...
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Influence of ovarian torsion on reproductive outcomes and mode of delivery

Frontiers in Medicine
PurposeTo investigate differences in reproductive outcomes among patients before and following ovarian torsion.Study designIn this retrospective cohort study, we investigated the reproductive outcomes of patients who underwent surgery for ovarian torsion
Tali Silberstein, Amir Freud, Yael Baumfeld, Yael Baumfeld, Eyal Sheiner, Adi Yehuda Weintraub, Salvatore Andrea Mastrolia, Salvatore Andrea Mastrolia, Giuseppe Trojano, Eli Harris Bernstein, Polina Schwarzman   +10 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source